高BMI和吸烟共同导致COPD:一项孟德尔随机研究。

IF 3.4 3区 医学 Q1 RESPIRATORY SYSTEM
Heidi Mikkelsen, Eskild Morten Landt, Sarah Caroline Weisenfeldt Marott, Marianne Benn, Børge Grønne Nordestgaard, Morten Dahl
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引用次数: 0

摘要

背景:我们检验了遗传上高体重指数(BMI)和遗传上高吸烟与慢性阻塞性肺疾病(COPD)风险的因果关系比单独的风险因素高的假设。方法:我们使用了两项基于丹麦人群的大型队列研究,哥本哈根城市心脏研究和哥本哈根一般人群研究,这些研究与丹麦国家患者出院和死亡登记处有关。对于遗传分析,我们纳入了112943名成年人,对5种BMI和1种吸烟增加基因变异进行了基因分型。通过使用BMI和吸烟的等位基因评分,对COPD的风险因素组合和单独进行95% ci的风险比估计。结果:高BMI和吸烟分别增加COPD的风险。结论:因果性、遗传性高BMI和吸烟联合导致COPD的风险高于单独使用这两种危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

High BMI and smoking jointly cause COPD: a Mendelian randomisation study.

High BMI and smoking jointly cause COPD: a Mendelian randomisation study.

High BMI and smoking jointly cause COPD: a Mendelian randomisation study.

High BMI and smoking jointly cause COPD: a Mendelian randomisation study.

Background: We tested the hypothesis that genetically high body mass index (BMI) and genetically high tobacco smoking jointly are causally associated with a higher risk of chronic obstructive pulmonary disease (COPD) than each risk factor alone.

Methods: We used two large Danish population-based cohort studies, The Copenhagen City Heart Study and the Copenhagen General Population Study linked to national Danish patient discharge and death registries. For the genetic analysis, we included 112 943 adults genotyped for five BMI and one tobacco smoking increasing gene variant. Risk ratios with 95% CIs for COPD were estimated for the risk factors in combination and individually by use of allele scores for BMI and smoking.

Results: Separately, both high BMI and tobacco smoking increased the risk for COPD (Ps<0.001), yet the highest risk was observed in the group of individuals with a combination of high allele scores for both high BMI and tobacco smoking (Ps≤0.04). Observationally, the highest risk for COPD was observed in the groups of people having high cumulative use of tobacco smoking, irrespective of BMI.

Conclusions: The combination of causal, genetically high BMI and tobacco smoking resulted in a higher risk for COPD than the two risk factors alone.

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来源期刊
BMJ Open Respiratory Research
BMJ Open Respiratory Research RESPIRATORY SYSTEM-
CiteScore
6.60
自引率
2.40%
发文量
95
审稿时长
12 weeks
期刊介绍: BMJ Open Respiratory Research is a peer-reviewed, open access journal publishing respiratory and critical care medicine. It is the sister journal to Thorax and co-owned by the British Thoracic Society and BMJ. The journal focuses on robustness of methodology and scientific rigour with less emphasis on novelty or perceived impact. BMJ Open Respiratory Research operates a rapid review process, with continuous publication online, ensuring timely, up-to-date research is available worldwide. The journal publishes review articles and all research study types: Basic science including laboratory based experiments and animal models, Pilot studies or proof of concept, Observational studies, Study protocols, Registries, Clinical trials from phase I to multicentre randomised clinical trials, Systematic reviews and meta-analyses.
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