成人唐氏综合征和结构正常心脏的无症状完全性心脏传导阻滞：罕见的关联。

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

Annals of African Medicine Pub Date : 2025-09-15 DOI:10.4103/aam.aam_234_25

Sangram Mangudkar, Nallani Chakravarthi Sai Sirisha, Vijayashree Gokhale, Divam Prakash Singh

{"title":"成人唐氏综合征和结构正常心脏的无症状完全性心脏传导阻滞：罕见的关联。","authors":"Sangram Mangudkar, Nallani Chakravarthi Sai Sirisha, Vijayashree Gokhale, Divam Prakash Singh","doi":"10.4103/aam.aam_234_25","DOIUrl":null,"url":null,"abstract":"Abstract: Down's syndrome (DS) is caused by an extra copy of the chromosome 21. Patients with DS have short stature, intellectual impairment, and characteristic physical features. Cardiovascular disease is the leading cause of morbidity and mortality in patients with DS. An estimated 40%-60% of DS patients have congenital heart disease (CHD). Cardiac conduction disturbances in association with CHD have been described in patients with DS. However, isolated cardiac conduction defect is exceptionally rare in DS, and we report an unusual case of asymptomatic complete heart block in an adult case of DS with structurally normal heart and review the literature about the conduction disturbances in DS.","PeriodicalId":7938,"journal":{"name":"Annals of African Medicine","volume":" ","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Asymptomatic Complete Heart Block in an Adult with Down's Syndrome and Structurally Normal Heart: A Rare Association.\",\"authors\":\"Sangram Mangudkar, Nallani Chakravarthi Sai Sirisha, Vijayashree Gokhale, Divam Prakash Singh\",\"doi\":\"10.4103/aam.aam_234_25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Abstract: Down's syndrome (DS) is caused by an extra copy of the chromosome 21. Patients with DS have short stature, intellectual impairment, and characteristic physical features. Cardiovascular disease is the leading cause of morbidity and mortality in patients with DS. An estimated 40%-60% of DS patients have congenital heart disease (CHD). Cardiac conduction disturbances in association with CHD have been described in patients with DS. However, isolated cardiac conduction defect is exceptionally rare in DS, and we report an unusual case of asymptomatic complete heart block in an adult case of DS with structurally normal heart and review the literature about the conduction disturbances in DS.\",\"PeriodicalId\":7938,\"journal\":{\"name\":\"Annals of African Medicine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of African Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/aam.aam_234_25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of African Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/aam.aam_234_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

摘要

摘要：唐氏综合症（DS）是由21号染色体的额外拷贝引起的。退行性椎体滑移患者有身材矮小、智力障碍和特征性的身体特征。心血管疾病是退行性椎体滑移患者发病和死亡的主要原因。估计40%-60%的退行性椎体滑移患者患有先天性心脏病（CHD）。在退行性椎体滑移患者中有与冠心病相关的心脏传导障碍的报道。然而，孤立的心脏传导缺陷在退行性椎体滑移中是非常罕见的，我们报告了一例心脏结构正常的成年退行性椎体滑移患者出现无症状的完全性心脏传导阻滞的罕见病例，并回顾了有关退行性椎体滑移传导障碍的文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Asymptomatic Complete Heart Block in an Adult with Down's Syndrome and Structurally Normal Heart: A Rare Association.

Abstract: Down's syndrome (DS) is caused by an extra copy of the chromosome 21. Patients with DS have short stature, intellectual impairment, and characteristic physical features. Cardiovascular disease is the leading cause of morbidity and mortality in patients with DS. An estimated 40%-60% of DS patients have congenital heart disease (CHD). Cardiac conduction disturbances in association with CHD have been described in patients with DS. However, isolated cardiac conduction defect is exceptionally rare in DS, and we report an unusual case of asymptomatic complete heart block in an adult case of DS with structurally normal heart and review the literature about the conduction disturbances in DS.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Annals of African Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

0.90

自引率

0.00%

发文量

期刊介绍： The Annals of African Medicine is published by the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria and the Annals of African Medicine Society. The Journal is intended to serve as a medium for the publication of research findings in the broad field of Medicine in Africa and other developing countries, and elsewhere which have relevance to Africa. It will serve as a source of information on the state of the art of Medicine in Africa, for continuing education for doctors in Africa and other developing countries, and also for the publication of meetings and conferences. The journal will publish articles I any field of Medicine and other fields which have relevance or implications for Medicine.