偏乙烯基和炔基[2 + 2]-环加成生成钴环丁烯的发散转化

IF 13.1 1区化学 Q1 CHEMISTRY, PHYSICAL

ACS Catalysis Pub Date : 2025-09-16 DOI:10.1021/acscatal.5c04303

Sourish Biswas, , , Wen Xiu, , , Abigail Soliven, , and , Christopher Uyeda*,

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引用次数: 0

摘要

钴催化的与炔相等的偏乙烯加成生成钴环丁烯中间体。在Zn(OTf)2的存在下，金属环经历Co-to-Zn金属转化过程，形成有机锌物质，可与水或其他亲电试剂猝灭，生成反式-1,3-二烯类产物。或者，在改性条件下，其他π体系截取金属环，得到环状多烯产物。这种双平台能够从单一中间体合成多种分子支架，并突出了偏乙烯转移反应产生的金属环的多功能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Divergent Transformations of Cobaltacyclobutenes Generated from [2 + 2]-Cycloadditions of Vinylidenes and Alkynes

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Divergent Transformations of Cobaltacyclobutenes Generated from [2 + 2]-Cycloadditions of Vinylidenes and Alkynes

A cobalt-catalyzed addition of a vinylidene equivalent to an alkyne generates a cobaltacyclobutene intermediate. In the presence of Zn(OTf)₂, the metallacycle undergoes a Co-to-Zn transmetalation process to form an organozinc species, amenable to quenching with water or other electrophiles to yield trans-1,3-dienoid products. Alternatively, interception of the metallacycle by other π-systems under modified conditions furnishes cyclic polyene products. This dual platform enables the synthesis of diverse molecular scaffolds from a single intermediate and highlights the versatility of metallacycles generated by vinylidene transfer reactions.

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来源期刊

ACS Catalysis CHEMISTRY, PHYSICAL-

CiteScore

20.80

自引率

6.20%

发文量

1253

审稿时长

1.5 months

期刊介绍： ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels. The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.