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ATG16L又来了！新发现将溶酶体应激与生理联系起来。

IF 6.4 1区 生物学 Q1 CELL BIOLOGY
Journal of Cell Biology Pub Date : 2025-09-16 DOI:10.1083/jcb.202509030
Alison D Klein,Michael Overholtzer
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引用次数: 0

摘要

溶酶体应激反应正在出现，但它们与正常生理的联系尚不清楚。在本期中，Duque等人（https://doi.org/10.1083/jcb.202503166）发现自噬蛋白ATG16L，一种称为CASM的应激反应介质，也调节正常溶酶体的功能。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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ATG16L strikes again! New findings link lysosome stress and physiology.
Lysosome stress responses are emerging, but their connections to normal physiology are not well understood. In this issue, Duque et al. (https://doi.org/10.1083/jcb.202503166) discover that the autophagy protein ATG16L, a mediator of a stress response called CASM, also regulates normal lysosome function.
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来源期刊
Journal of Cell Biology
Journal of Cell Biology 生物-细胞生物学
CiteScore
12.60
自引率
2.60%
发文量
213
审稿时长
1 months
期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.
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