细胞分辨率的顺式调控元件

IF 52 1区生物学 Q1 GENETICS & HEREDITY

Nature Reviews Genetics Pub Date : 2025-09-16 DOI:10.1038/s41576-025-00882-7

Yi Xiang See, Tim Stuart, Jay W. Shin

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引用次数: 0

摘要

单细胞分析技术的最新进展现在可以在不同的细胞类型、疾病状态和遗传背景下常规和可扩展地测量顺式调节元件的活性。现在是时候协调全球的努力，系统地绘制单细胞分辨率的顺式调控元件功能。在这篇评论中，作者概述了一些关键的下一步，以提高我们对单细胞分辨率顺式调控元件的理解，其中包括协调全球努力构建一个全面的单细胞基因调控图谱。

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Cis-regulatory elements at cellular resolution

Recent advances in single-cell profiling technologies now enable routine and scalable measurements of cis-regulatory element activity across diverse cell types, disease states and genetic backgrounds. It is time to coordinate a global effort to systematically map cis-regulatory element function at single-cell resolution. In this Comment, the authors outline some key next steps to advance our understanding of cis-regulatory elements at single-cell resolution, which includes harmonizing global efforts to construct a comprehensive single-cell atlas of gene regulation.

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来源期刊

Nature Reviews Genetics 生物-遗传学

CiteScore

57.40

自引率

0.50%

发文量

113

审稿时长

6-12 weeks

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