蒸汽辅助呼吸肌训练对男女睡眠呼吸暂停症状和肺功能的影响:一项初步研究

IF 2
U Al-Rammahi, T Soukka, J Malinen, R P Happonen, A Sovijärvi, U Anttalainen
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引用次数: 0

摘要

目的:阻塞性睡眠呼吸暂停(OSA)会对生活质量产生负面影响,并增加心血管和代谢风险。虽然持续气道正压是金标准治疗,但有限的依从性降低了其临床效果。本研究探讨蒸汽辅助呼吸肌训练(RMT)是否能缓解OSA患者的症状,改善肺功能,并探讨男女患者在反应上的潜在差异。方法:这项开放标签、为期12周的前瞻性先导研究纳入了60名轻度至中度OSA患者,他们进行了个性化的吸气和呼气反压呼吸练习,并伴有蒸汽吸入。在基线和干预后进行肺功能检查、睡眠相关问卷和一般健康评估。表现出较基线显著改善的参与者被归类为高应答者,进行亚组分析。结果:60名参与者中有33名的最终结果显示显着的平均改善,失眠严重指数(ISI)下降1.8分,匹兹堡睡眠质量指数(PSQI)下降2分,12项一般健康问卷(GHQ-12)下降7.9分(均为p)结论:RMT可以作为以患者为中心的治疗轻中度OSA症状负担的替代方案。虽然需要更大规模的试验来证实这些初步发现,但这些试点结果尚未显示出持续的益处,应谨慎解释。临床试验网站ClinicalTrials.gov,注册号:NCT05320952。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effects of steam-assisted respiratory muscle training on sleep apnoea symptoms and pulmonary function in men and women: a pilot study.

Effects of steam-assisted respiratory muscle training on sleep apnoea symptoms and pulmonary function in men and women: a pilot study.

Effects of steam-assisted respiratory muscle training on sleep apnoea symptoms and pulmonary function in men and women: a pilot study.

Purpose: Obstructive sleep apnoea (OSA) negatively impacts quality of life and increases cardiovascular and metabolic risks. Although continuous positive airway pressure is the gold-standard treatment, limited adherence reduces its clinical effectiveness. This study investigates whether steam-assisted respiratory muscle training (RMT) can alleviate symptoms, improve pulmonary function, and explore potential differences in response between men and women with OSA.

Methods: This open-label, 12-week prospective pilot study included 60 participants with mild to moderate OSA, who performed individualized inspiratory and expiratory counter-pressure breathing exercises with steam inhalation. Pulmonary function tests, sleep-related questionnaires, and general health assessments were conducted at baseline and post-intervention. Participants showing notable improvements from baseline were classified as high responders, enabling subgroup analyses.

Results: Final results of 33 of the 60 participants showed significant mean improvements, with the Insomnia Severity Index (ISI) decreasing by 1.8 points, the Pittsburgh Sleep Quality Index (PSQI) by 2 points, and the 12-item General Health Questionnaire (GHQ-12) by 7.9 points (all p < 0.01). Forced expiratory volume in one second (FEV₁) increased from from 3.6 L to 3.8 L (p = 0.04). Subgroup analysis revealed an enhancement in sleep-related symptoms and pulmonary function.

Conclusions: RMT may serve as a patient-centered alternative for managing the symptomatic burden of mild to moderate OSA. While larger trials are needed to confirm these preliminary findings, these pilot results do not yet demonstrate sustained benefit and should be interpreted with caution. Trial registration ClinicalTrials.gov, register no. NCT05320952.

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