EXPRESS: Advancement of an (In Vitro/Ex Vivo) Hybrid Model Framework to Forecast Polyviral Lung Disease Outcomes.

The advancement of an (in vitro/ex vivo) hybrid model framework for forecasting polyviral lung disease outcomes addresses the pressing need for sophisticated tools to understand the complexities of these infections. The primary objective of this study is to advance the development and application of an (in vitro/ex vivo) hybrid model framework for forecasting polyviral lung disease outcomes. This phase of data collection for lung infections, involving single and co-infecting viruses, utilizes ex vivo models (perfused lung tissue slices) and in vitro models (lung cell cultures). Before employing Local Binary Patterns (LBP) for image analysis, data pre-processing, including Weighted Local Gabor Binary Pattern (WLGBP), is essential. Feature extraction is a critical initial step in enhancing the dataset for developing a hybrid model framework (in vitro/ex vivo) to predict polyviral lung disease outcomes. By employing VGG16 and CBRACDC algorithms, a hybrid model framework (in vitro/ex vivo) is created to forecast polyviral lung disease outcomes. Incorporating the Random Survival Forest (RSF) algorithm into the hybrid model framework brings numerous benefits for polyviral lung disease prognosis. Python was utilized extensively throughout the development and analysis phases, contributing to the framework's robustness and versatility. The observed minimum cost value of 1.079 indicates the algorithm's optimal performance based on the defined objective. Future research avenues could focus on integrating advanced computational techniques like deep learning and artificial intelligence to improve the predictive accuracy and scalability of hybrid models for forecasting polyviral lung disease outcomes. This could enable personalized medicine approaches and more targeted therapeutic interventions.