TMEM16A对胃肠道和血管平滑肌收缩力的影响。

IF 4.4 2区医学 Q1 NEUROSCIENCES

Journal of Physiology-London Pub Date : 2025-09-14 DOI:10.1113/JP289160

Sadik Taskin Tas, Marc O Anderson, Onur Cil

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引用次数: 0

摘要

钙活化Cl-通道（Calcium-activated Cl- channels, CaCC）是一种广泛表达的调节多种生理功能的蛋白。TMEM16A是一种表达于胃肠道和心血管系统的CaCC，是组织收缩的主要调节因子。本文综述了TMEM16A在胃肠道和血管平滑肌收缩性中的作用，包括其片段和细胞类型特异性作用的最新进展。我们还讨论了最近的生理和药理学证据，表明TMEM16A调节剂在与平滑肌收缩性改变相关的胃肠道和心血管疾病中具有潜在的治疗作用。

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TMEM16A in gastrointestinal and vascular smooth muscle contractility.

Calcium-activated Cl^- channels (CaCC) are widely expressed proteins which regulate various physiological functions. TMEM16A is a CaCC expressed in the gastrointestinal and cardiovascular systems, where it is a major regulator of tissue contraction. In this review we discuss recent advances on the roles of TMEM16A in gastrointestinal and vascular smooth muscle contractility, including its segment and cell type-specific effects. We also discuss recent physiological and pharmacological evidence suggesting potential therapeutic utility of TMEM16A modulators in gastrointestinal and cardiovascular diseases associated with altered smooth muscle contractility.

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来源期刊

Journal of Physiology-London 医学-神经科学

CiteScore

9.70

自引率

7.30%

发文量

817

审稿时长

2 months

期刊介绍： The Journal of Physiology publishes full-length original Research Papers and Techniques for Physiology, which are short papers aimed at disseminating new techniques for physiological research. Articles solicited by the Editorial Board include Perspectives, Symposium Reports and Topical Reviews, which highlight areas of special physiological interest. CrossTalk articles are short editorial-style invited articles framing a debate between experts in the field on controversial topics. Letters to the Editor and Journal Club articles are also published. All categories of papers are subjected to peer reivew. The Journal of Physiology welcomes submitted research papers in all areas of physiology. Authors should present original work that illustrates new physiological principles or mechanisms. Papers on work at the molecular level, at the level of the cell membrane, single cells, tissues or organs and on systems physiology are all acceptable. Theoretical papers and papers that use computational models to further our understanding of physiological processes will be considered if based on experimentally derived data and if the hypothesis advanced is directly amenable to experimental testing. While emphasis is on human and mammalian physiology, work on lower vertebrate or invertebrate preparations may be suitable if it furthers the understanding of the functioning of other organisms including mammals.