{"title":"环状RNA在新发传染病疫苗和药物开发中的潜力和挑战。","authors":"Keda Chen, Yutong Xu, Jiaxuan Li, Siyi Gu, Zhiyi Wang, Jianhua Li, Yanjun Zhang","doi":"10.1016/j.omtn.2025.102687","DOIUrl":null,"url":null,"abstract":"<p><p>Circular RNAs (circRNAs) are a class of RNA molecules with a covalent closed-loop structure that play important roles in the regulation of biological processes and disease genesis. In recent years, circRNAs have become a research hotspot due to their unique stability and biological functions. Compared with linear RNAs, synthetic circRNAs have higher stability and show great potential in therapeutic applications. Although circRNA technology is still at an early stage of development, breakthroughs in mRNA technology provide an important reference for its application. This review systematically explores the promising applications of circRNAs in vaccine development and drug research, evaluates their feasibility as vaccine components and drug carriers, and experimentally validates their efficacy in disease models. At the same time, this paper analyzes the advantages and challenges of circRNA application in depth and looks forward to the future research direction, which provides new ideas for the prevention and treatment of new outbreaks of infectious diseases.</p>","PeriodicalId":18821,"journal":{"name":"Molecular Therapy. Nucleic Acids","volume":"36 3","pages":"102687"},"PeriodicalIF":6.1000,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423345/pdf/","citationCount":"0","resultStr":"{\"title\":\"The potential and challenges of circular RNA in the development of vaccines and drugs for emerging infectious diseases.\",\"authors\":\"Keda Chen, Yutong Xu, Jiaxuan Li, Siyi Gu, Zhiyi Wang, Jianhua Li, Yanjun Zhang\",\"doi\":\"10.1016/j.omtn.2025.102687\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Circular RNAs (circRNAs) are a class of RNA molecules with a covalent closed-loop structure that play important roles in the regulation of biological processes and disease genesis. In recent years, circRNAs have become a research hotspot due to their unique stability and biological functions. Compared with linear RNAs, synthetic circRNAs have higher stability and show great potential in therapeutic applications. Although circRNA technology is still at an early stage of development, breakthroughs in mRNA technology provide an important reference for its application. This review systematically explores the promising applications of circRNAs in vaccine development and drug research, evaluates their feasibility as vaccine components and drug carriers, and experimentally validates their efficacy in disease models. At the same time, this paper analyzes the advantages and challenges of circRNA application in depth and looks forward to the future research direction, which provides new ideas for the prevention and treatment of new outbreaks of infectious diseases.</p>\",\"PeriodicalId\":18821,\"journal\":{\"name\":\"Molecular Therapy. Nucleic Acids\",\"volume\":\"36 3\",\"pages\":\"102687\"},\"PeriodicalIF\":6.1000,\"publicationDate\":\"2025-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423345/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Therapy. Nucleic Acids\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.omtn.2025.102687\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/9 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Therapy. Nucleic Acids","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.omtn.2025.102687","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/9 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
The potential and challenges of circular RNA in the development of vaccines and drugs for emerging infectious diseases.
Circular RNAs (circRNAs) are a class of RNA molecules with a covalent closed-loop structure that play important roles in the regulation of biological processes and disease genesis. In recent years, circRNAs have become a research hotspot due to their unique stability and biological functions. Compared with linear RNAs, synthetic circRNAs have higher stability and show great potential in therapeutic applications. Although circRNA technology is still at an early stage of development, breakthroughs in mRNA technology provide an important reference for its application. This review systematically explores the promising applications of circRNAs in vaccine development and drug research, evaluates their feasibility as vaccine components and drug carriers, and experimentally validates their efficacy in disease models. At the same time, this paper analyzes the advantages and challenges of circRNA application in depth and looks forward to the future research direction, which provides new ideas for the prevention and treatment of new outbreaks of infectious diseases.
期刊介绍：
Molecular Therapy Nucleic Acids is an international, open-access journal that publishes high-quality research in nucleic-acid-based therapeutics to treat and correct genetic and acquired diseases. It is the official journal of the American Society of Gene & Cell Therapy and is built upon the success of Molecular Therapy. The journal focuses on gene- and oligonucleotide-based therapies and publishes peer-reviewed research, reviews, and commentaries. Its impact factor for 2022 is 8.8. The subject areas covered include the development of therapeutics based on nucleic acids and their derivatives, vector development for RNA-based therapeutics delivery, utilization of gene-modifying agents like Zn finger nucleases and triplex-forming oligonucleotides, pre-clinical target validation, safety and efficacy studies, and clinical trials.
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