Pradeed Kumar Yadalam, Parkavi Arumugam, Sai Keerthana Melanathuru-Balanatha, Carlos M Ardila
{"title":"引导骨再生中可吸收螺钉用镁板上的锶锌转化涂层：表征和生物相容性评价。","authors":"Pradeed Kumar Yadalam, Parkavi Arumugam, Sai Keerthana Melanathuru-Balanatha, Carlos M Ardila","doi":"10.4317/jced.62819","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Guided bone regeneration (GBR) requires resorbable implants that balance corrosion resistance and biocompatibility. Magnesium (Mg) is a promising candidate, but its rapid degradation necessitates protective coatings. This study develops and characterizes a strontium-zinc (Sr-Zn) conversion coating on Mg plates for resorbable tack screws, evaluating its corrosion resistance, surface properties, and biocompatibility.</p><p><strong>Material and methods: </strong>Mg plates (20×15×2 mm) were etched with HCl, coated with Sr-Zn via immersion (30 min, pH 3-5), and characterized using SEM, EDX, and FTIR. Corrosion resistance was assessed via potentiodynamic polarization in simulated body fluid (SBF). Biocompatibility was evaluated using MG63 osteoblast cultures, with statistical comparison (Student's t-test, <i>p</i> < 0.05) between coated (Group A) and uncoated (Group B) plates.</p><p><strong>Results: </strong>SEM revealed a dense, fibrous coating with interconnected pores, enhancing cell adhesion. EDX confirmed Zn (46.6 wt%) and Sr (3.7 wt%) incorporation. FTIR identified hydroxyl/carbonyl groups and metal-oxygen bonds. The coating improved corrosion resistance compared to bare Mg plates. In vitro cell culture assays demonstrated that Sr-Zn conversion-coated Mg plates (Group A) showed comparable cell viability to bare Mg plates (Group B) at all tested time points. Peak cell viability was recorded at 24 hours, with Group A achieving 92.66% and Group B reaching 91% (<i>p</i> = 0.238). This statistically non-significant difference suggests successful biocompatibility of the Sr-Zn coating. The enhanced biocompatibility observed is likely attributed to the coating's improved corrosion resistance.</p><p><strong>Conclusions: </strong>The Sr-Zn coating improved Mg's corrosion resistance while maintaining osteoblast viability, supporting its potential for resorbable GBR tack screws. <b>Key words:</b>Guided bone regeneration, Magnesium implants, Strontium-zinc coating, Corrosion resistance, Biocompatibility, Resorbable screws.</p>","PeriodicalId":15376,"journal":{"name":"Journal of Clinical and Experimental Dentistry","volume":"17 8","pages":"e936-e942"},"PeriodicalIF":0.0000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424584/pdf/","citationCount":"0","resultStr":"{\"title\":\"Strontium-Zinc conversion coating on magnesium plates for resorbable tack screws in guided bone regeneration: Characterization and biocompatibility evaluation.\",\"authors\":\"Pradeed Kumar Yadalam, Parkavi Arumugam, Sai Keerthana Melanathuru-Balanatha, Carlos M Ardila\",\"doi\":\"10.4317/jced.62819\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Guided bone regeneration (GBR) requires resorbable implants that balance corrosion resistance and biocompatibility. Magnesium (Mg) is a promising candidate, but its rapid degradation necessitates protective coatings. This study develops and characterizes a strontium-zinc (Sr-Zn) conversion coating on Mg plates for resorbable tack screws, evaluating its corrosion resistance, surface properties, and biocompatibility.</p><p><strong>Material and methods: </strong>Mg plates (20×15×2 mm) were etched with HCl, coated with Sr-Zn via immersion (30 min, pH 3-5), and characterized using SEM, EDX, and FTIR. Corrosion resistance was assessed via potentiodynamic polarization in simulated body fluid (SBF). Biocompatibility was evaluated using MG63 osteoblast cultures, with statistical comparison (Student's t-test, <i>p</i> < 0.05) between coated (Group A) and uncoated (Group B) plates.</p><p><strong>Results: </strong>SEM revealed a dense, fibrous coating with interconnected pores, enhancing cell adhesion. EDX confirmed Zn (46.6 wt%) and Sr (3.7 wt%) incorporation. FTIR identified hydroxyl/carbonyl groups and metal-oxygen bonds. The coating improved corrosion resistance compared to bare Mg plates. In vitro cell culture assays demonstrated that Sr-Zn conversion-coated Mg plates (Group A) showed comparable cell viability to bare Mg plates (Group B) at all tested time points. Peak cell viability was recorded at 24 hours, with Group A achieving 92.66% and Group B reaching 91% (<i>p</i> = 0.238). This statistically non-significant difference suggests successful biocompatibility of the Sr-Zn coating. The enhanced biocompatibility observed is likely attributed to the coating's improved corrosion resistance.</p><p><strong>Conclusions: </strong>The Sr-Zn coating improved Mg's corrosion resistance while maintaining osteoblast viability, supporting its potential for resorbable GBR tack screws. <b>Key words:</b>Guided bone regeneration, Magnesium implants, Strontium-zinc coating, Corrosion resistance, Biocompatibility, Resorbable screws.</p>\",\"PeriodicalId\":15376,\"journal\":{\"name\":\"Journal of Clinical and Experimental Dentistry\",\"volume\":\"17 8\",\"pages\":\"e936-e942\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424584/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical and Experimental Dentistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4317/jced.62819\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Dentistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical and Experimental Dentistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4317/jced.62819","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}
Strontium-Zinc conversion coating on magnesium plates for resorbable tack screws in guided bone regeneration: Characterization and biocompatibility evaluation.
Background: Guided bone regeneration (GBR) requires resorbable implants that balance corrosion resistance and biocompatibility. Magnesium (Mg) is a promising candidate, but its rapid degradation necessitates protective coatings. This study develops and characterizes a strontium-zinc (Sr-Zn) conversion coating on Mg plates for resorbable tack screws, evaluating its corrosion resistance, surface properties, and biocompatibility.
Material and methods: Mg plates (20×15×2 mm) were etched with HCl, coated with Sr-Zn via immersion (30 min, pH 3-5), and characterized using SEM, EDX, and FTIR. Corrosion resistance was assessed via potentiodynamic polarization in simulated body fluid (SBF). Biocompatibility was evaluated using MG63 osteoblast cultures, with statistical comparison (Student's t-test, p < 0.05) between coated (Group A) and uncoated (Group B) plates.
Results: SEM revealed a dense, fibrous coating with interconnected pores, enhancing cell adhesion. EDX confirmed Zn (46.6 wt%) and Sr (3.7 wt%) incorporation. FTIR identified hydroxyl/carbonyl groups and metal-oxygen bonds. The coating improved corrosion resistance compared to bare Mg plates. In vitro cell culture assays demonstrated that Sr-Zn conversion-coated Mg plates (Group A) showed comparable cell viability to bare Mg plates (Group B) at all tested time points. Peak cell viability was recorded at 24 hours, with Group A achieving 92.66% and Group B reaching 91% (p = 0.238). This statistically non-significant difference suggests successful biocompatibility of the Sr-Zn coating. The enhanced biocompatibility observed is likely attributed to the coating's improved corrosion resistance.
Conclusions: The Sr-Zn coating improved Mg's corrosion resistance while maintaining osteoblast viability, supporting its potential for resorbable GBR tack screws. Key words:Guided bone regeneration, Magnesium implants, Strontium-zinc coating, Corrosion resistance, Biocompatibility, Resorbable screws.
期刊介绍：
Indexed in PUBMED, PubMed Central® (PMC) since 2012 and SCOPUSJournal of Clinical and Experimental Dentistry is an Open Access (free access on-line) - http://www.medicinaoral.com/odo/indice.htm. The aim of the Journal of Clinical and Experimental Dentistry is: - Periodontology - Community and Preventive Dentistry - Esthetic Dentistry - Biomaterials and Bioengineering in Dentistry - Operative Dentistry and Endodontics - Prosthetic Dentistry - Orthodontics - Oral Medicine and Pathology - Odontostomatology for the disabled or special patients - Oral Surgery
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