评论“真菌衍生的具有抗菌性能的壳聚糖基水凝胶用于感染性伤口愈合”。醛修饰壳聚糖的结构尚不清楚。

IF 12.5 1区化学 Q1 CHEMISTRY, APPLIED

Carbohydrate Polymers Pub Date : 2025-11-15 Epub Date: 2025-08-06 DOI:10.1016/j.carbpol.2025.124177

Zuhan Chen

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引用次数: 0

摘要

Zhou等人（https://doi.org/10.1016/j.carbpol.2025.123917）利用真菌衍生的壳聚糖合成了胍功能化壳聚糖（GCS）和醛修饰壳聚糖（ACS），用于席夫碱水凝胶的形成。为了完整起见，澄清ACS是否可能在所使用的条件下进行任何自交联或自凝胶化，并讨论其在希夫碱网络中作为醛给体的特定适用性是有价值的。这一评论强调了ACS更精确的结构定义的重要性，特别是关于其在希夫碱反应中的作用。彻底的结构表征——最好是通过全面的核磁共振分析——将验证改性的程度，并阐明其在交联机制中的确切作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comment on "Fungal-derived chitosan-based hydrogels with antimicrobial properties for infectious wound healing". The structure of aldehyde-modified chitosan is unclear.

Zhou et al. (https://doi.org/10.1016/j.carbpol.2025.123917) employed fungal-derived chitosan to synthesize guanidinium-functionalized chitosan (GCS) and aldehyde-modified chitosan (ACS) for Schiff-base hydrogel formation. For completeness, it would be valuable to clarify whether ACS might undergo any self-crosslinking or self-gelation under the conditions used, and to discuss its specific suitability as the aldehyde donor within the Schiff-base network. This comment underscores the importance of a more precise structural definition of ACS, especially concerning its function in the Schiff-base reaction. A thorough structural characterization-ideally via comprehensive NMR analysis-will verify the degree of modification and clarify its exact role in the crosslinking mechanism.

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来源期刊

Carbohydrate Polymers 化学-高分子科学

CiteScore

22.40

自引率

8.00%

发文量

1286

审稿时长

47 days

期刊介绍： Carbohydrate Polymers stands as a prominent journal in the glycoscience field, dedicated to exploring and harnessing the potential of polysaccharides with applications spanning bioenergy, bioplastics, biomaterials, biorefining, chemistry, drug delivery, food, health, nanotechnology, packaging, paper, pharmaceuticals, medicine, oil recovery, textiles, tissue engineering, wood, and various aspects of glycoscience. The journal emphasizes the central role of well-characterized carbohydrate polymers, highlighting their significance as the primary focus rather than a peripheral topic. Each paper must prominently feature at least one named carbohydrate polymer, evident in both citation and title, with a commitment to innovative research that advances scientific knowledge.