Patrick Lao, Natalie Edwards, Lisi Flores-Aguilar, Mohamad J. Alshikho, Anna Smith, Rachel LeMay, Juyoung Hahm, Batool Rizvi, Dana Tudorascu, H. Diana Rosas, Michael Yassa, Bradley Christian, Mark Mapstone, Benjamin Handen, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators, Jose Gutierrez, Donna Wilcock, Elizabeth Head, Adam M. Brickman
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Annualized WMH change was assessed across cognitive diagnostic groups defined by progression or stability between two visits (78% remained cognitively stable (CS), 6% progressed from CS to mild cognitive impairment [MCI]-DS, 5% remained MCI-DS, 6% progressed from MCI-DS to AD, 4% remained AD).</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Compared to those who remained CS, WMH changes, particularly in posterior regions, over time were faster in advanced diagnostic groups (i.e., MCI-DS to AD, AD at both timepoints). Monotonic increase across progressive diagnostic groups suggest an acceleration in WMH over time.</p>\n </section>\n \n <section>\n \n <h3> CONCLUSION</h3>\n \n <p>Posterior WMH accelerates with AD progression in adults with DS beginning at the progression from MCI-DS to AD.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>White matter hyperintensity (WMH) volume increased and decreased over time in adults with Down syndrome.</li>\n \n <li>WMH decreased over time in the cognitively stable group.</li>\n \n <li>WMH increased over time in advanced Alzheimer's disease diagnostic groups.</li>\n \n <li>Change in posterior WMH accelerated across progressive Alzheimer's disease groups.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 9","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70679","citationCount":"0","resultStr":"{\"title\":\"Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome\",\"authors\":\"Patrick Lao, Natalie Edwards, Lisi Flores-Aguilar, Mohamad J. Alshikho, Anna Smith, Rachel LeMay, Juyoung Hahm, Batool Rizvi, Dana Tudorascu, H. Diana Rosas, Michael Yassa, Bradley Christian, Mark Mapstone, Benjamin Handen, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators, Jose Gutierrez, Donna Wilcock, Elizabeth Head, Adam M. Brickman\",\"doi\":\"10.1002/alz.70679\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> INTRODUCTION</h3>\\n \\n <p>Cerebrovascular disease is elevated across the Alzheimer's disease (AD) continuum in adults with Down syndrome (DS), but regional change within individuals is unknown.</p>\\n </section>\\n \\n <section>\\n \\n <h3> METHODS</h3>\\n \\n <p>Participants from the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study (<i>n</i> = 187) had magnetic resonance imaging (MRI) scans quantified for white matter hyperintensity (WMH) volume. Annualized WMH change was assessed across cognitive diagnostic groups defined by progression or stability between two visits (78% remained cognitively stable (CS), 6% progressed from CS to mild cognitive impairment [MCI]-DS, 5% remained MCI-DS, 6% progressed from MCI-DS to AD, 4% remained AD).</p>\\n </section>\\n \\n <section>\\n \\n <h3> RESULTS</h3>\\n \\n <p>Compared to those who remained CS, WMH changes, particularly in posterior regions, over time were faster in advanced diagnostic groups (i.e., MCI-DS to AD, AD at both timepoints). Monotonic increase across progressive diagnostic groups suggest an acceleration in WMH over time.</p>\\n </section>\\n \\n <section>\\n \\n <h3> CONCLUSION</h3>\\n \\n <p>Posterior WMH accelerates with AD progression in adults with DS beginning at the progression from MCI-DS to AD.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>White matter hyperintensity (WMH) volume increased and decreased over time in adults with Down syndrome.</li>\\n \\n <li>WMH decreased over time in the cognitively stable group.</li>\\n \\n <li>WMH increased over time in advanced Alzheimer's disease diagnostic groups.</li>\\n \\n <li>Change in posterior WMH accelerated across progressive Alzheimer's disease groups.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 9\",\"pages\":\"\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://alz-journals.onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70679\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70679\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.70679","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Longitudinal changes in white matter hyperintensity volume accelerate across the Alzheimer's continuum in adults with Down syndrome
INTRODUCTION
Cerebrovascular disease is elevated across the Alzheimer's disease (AD) continuum in adults with Down syndrome (DS), but regional change within individuals is unknown.
METHODS
Participants from the Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study (n = 187) had magnetic resonance imaging (MRI) scans quantified for white matter hyperintensity (WMH) volume. Annualized WMH change was assessed across cognitive diagnostic groups defined by progression or stability between two visits (78% remained cognitively stable (CS), 6% progressed from CS to mild cognitive impairment [MCI]-DS, 5% remained MCI-DS, 6% progressed from MCI-DS to AD, 4% remained AD).
RESULTS
Compared to those who remained CS, WMH changes, particularly in posterior regions, over time were faster in advanced diagnostic groups (i.e., MCI-DS to AD, AD at both timepoints). Monotonic increase across progressive diagnostic groups suggest an acceleration in WMH over time.
CONCLUSION
Posterior WMH accelerates with AD progression in adults with DS beginning at the progression from MCI-DS to AD.
Highlights
White matter hyperintensity (WMH) volume increased and decreased over time in adults with Down syndrome.
WMH decreased over time in the cognitively stable group.
WMH increased over time in advanced Alzheimer's disease diagnostic groups.
Change in posterior WMH accelerated across progressive Alzheimer's disease groups.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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