MoS2-driven visible light photocatalytic oxidation for sustainable synthesis of quinazolin-4(3H)-one in water

The development of sustainable catalytic methods is essential for green chemistry, minimizing the environmental impact while maximizing efficiency. This study presents an eco-friendly and energy-efficient strategy for synthesizing quinazolin-4(3H)-one using molybdenum disulfide (MoS₂) as a visible-light photocatalyst in water. The method utilizes the exceptional catalytic properties of MoS₂, including its high surface area, and enhanced charge separation under visible light irradiation. Blue visible light activation facilitates oxidative cyclization of aromatic aldehydes with anthranilamide under mild conditions. Water, serving as the reaction medium, enhances the reaction efficiency by reducing solvent waste and toxicity. The combination of visible-light photocatalysis and an environmentally benign solvent provides a scalable, energy-efficient alternative for the synthesis of quinazolin-4(3H)-one and its derivatives, paving the way for greener methodologies in heterocyclic chemistry. Recyclability experiments revealed that MoS₂ retains its catalytic activity over multiple cycles, reinforcing its cost-effectiveness and sustainability.