Importance of hematological ratios in dogs with ovarian tumors

This study was conducted to evaluate - hematological and biochemical parameters in dogs with ovarian tumors and to compare these findings with those of healthy dogs. Additionally, the differences in platelet-derived markers (platelets (PLT), mean platelet volume (MPV)), hematological ratios, and total blood count parameters between healthy dogs and dogs with ovarian tumors were investigated. Forty-two intact female dogs were included in the study and divided into two groups based on the histopathological examination of the ovaries: the control group (Group C; n = 22), consisting of healthy dogs with no ovarian pathology, and the ovarian tumors group (Group OT; n = 20), consisting of bitches diagnosed with ovarian tumors. Ovarian tumors were classified into two main groups according to the WHO classification of tumors of the genital system of domestic animals: epithelial tumors (Group ET; n = 10) and sex cord-stromal tumors (Group SST; n = 10). Hematological and biochemical analyses were performed using blood samples collected before ovariohysterectomy. Leukocyte count (WBC), neutrophil count (NEU), platelet count (PLT), serum alkaline phosphatase (ALP), and cholesterol (CHOL) levels were found to be significantly higher in Group OT compared to Group C (p < 0.05). Furthermore, WBC, NEU, PLT, ALP, and CHOL values were significantly higher in dogs with epithelial tumors compared to those with sex cord-stromal tumors (p < 0.05). No statistically significant differences were detected in MPV and hematological ratios (NLR, PLR) between the ovarian tumor groups. These findings suggest that ovarian tumors may lead to alterations in hematological and biochemical parameters in dogs, and these changes may vary depending on the tumor type.