拟南芥中独角麦内酯信号抑制因子SMXL7通过jmj30介导的H3K27me3去甲基化调节基因组结构。

IF 8.1 1区生物学 Q1 PLANT SCIENCES

New Phytologist Pub Date : 2025-09-15 DOI:10.1111/nph.70580

Jindong Li,Gang Xu,Guangfeng Qu,Huihui Ma,Zhiyao He,Mingyu Sun,Lu Gao,Haiyang Yu,Yuehua Wang,Yunwei Zhang,Meng Zhang,Li Chen,Ruifeng Yao

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引用次数: 0

摘要

近年来的研究表明，表观遗传调控因子对植物中脱落酸、乙烯、茉莉酸、赤霉素和细胞分裂素等激素信号通路具有重要的调控作用。然而，独角麦内酯（SL）是否通过表观遗传机制调节染色质动力学和基因组结构在很大程度上仍未被探索。在这里，我们证明了MAX2-LIKE7的抑制因子（SMXL7），一个SL信号的抑制因子，在K27 （H3K27me3）介导的表观遗传调控中通过H3三甲基化重组色中心组织。此外，SMXL7与组蛋白H3K27me3相关的异染色质结合，并通过将组蛋白去甲基化酶JUMNOJI 30 （JMJ30）结合到SMXL7凝聚物中来控制全基因组的H3K27me3水平，调节染色质的可及性和基因组结构。我们的研究结果提供了SMXL7影响植物高阶染色质组织的证据，并提出了一种新的SL信号转导模式。

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Strigolactone signaling repressor SMXL7 modulates genome architecture via JMJ30-mediated H3K27me3 demethylation in Arabidopsis.

Recent advances indicate that epigenetic regulators critically govern hormone signaling networks, such as abscisic acid, ethylene, jasmonate, gibberellin, and cytokinin pathways in plants. Nevertheless, whether strigolactone (SL) modulates chromatin dynamics and genome architecture through epigenetic mechanisms remains largely unexplored. Here, we demonstrate that SUPPRESSOR OF MAX2-LIKE7 (SMXL7), a repressor of SL signaling, restructures chromocenter organization through H3 trimethylation at K27 (H3K27me3)-mediated epigenetic regulation. Moreover, SMXL7 associates with histone H3K27me3-related heterochromatin and controls genome-wide H3K27me3 levels through incorporating the histone demethylases JUMNOJI 30 (JMJ30) into the SMXL7 condensates, modulating chromatin accessibility and genome architecture. Our findings provide evidence that SMXL7 influences higher order chromatin organization in planta and suggest a novel mode of SL signal transduction.

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来源期刊

New Phytologist 生物-植物科学

自引率

5.30%

发文量

728

期刊介绍： New Phytologist is an international electronic journal published 24 times a year. It is owned by the New Phytologist Foundation, a non-profit-making charitable organization dedicated to promoting plant science. The journal publishes excellent, novel, rigorous, and timely research and scholarship in plant science and its applications. The articles cover topics in five sections: Physiology & Development, Environment, Interaction, Evolution, and Transformative Plant Biotechnology. These sections encompass intracellular processes, global environmental change, and encourage cross-disciplinary approaches. The journal recognizes the use of techniques from molecular and cell biology, functional genomics, modeling, and system-based approaches in plant science. Abstracting and Indexing Information for New Phytologist includes Academic Search, AgBiotech News & Information, Agroforestry Abstracts, Biochemistry & Biophysics Citation Index, Botanical Pesticides, CAB Abstracts®, Environment Index, Global Health, and Plant Breeding Abstracts, and others.