{"title":"那不勒斯预后评分在睾丸生殖细胞肿瘤中的预后作用：回顾性分析。","authors":"Hakan Tekinaslan, Osman Köse, Serkan Ozcan, Sacit Nuri Görgel, Yigit Akin","doi":"10.1159/000548383","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to evaluate the prognostic significance of the Naples Prognostic Score (NPS) in testicular germ cell tumors (TGCT), with a focus on its association with tumor stage, histological subtype, and survival outcomes.</p><p><strong>Methods: </strong>In this retrospective study, 133 patients with TGCT treated at a single tertiary center between 2015 and 2023 were evaluated. The NPS was calculated for each patient based on pre-treatment albumin, cholesterol, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR). Patients were stratified into low (0-2) and high (3-4) NPS groups. Clinicopathological characteristics were compared between NPS groups. Overall survival was analyzed using Kaplan-Meier estimates with log-rank tests, and Cox proportional hazards regression was performed to identify independent prognostic factors.</p><p><strong>Results: </strong>Patients with high NPS were significantly younger on average and more likely to have non-seminomatous histology, advanced clinical stage, elevated tumor markers, and metastatic disease compared to those with low NPS (all p < 0.01). Overall survival was markedly worse in the high NPS group (p < 0.005). On multivariate analysis, NPS emerged as an independent predictor of poorer overall survival alongside clinical stage (hazard ratio for high NPS ∼ 8.4, p = 0.018).</p><p><strong>Conclusion: </strong>The NPS is a significant prognostic indicator in TGCT. A high NPS is associated with aggressive disease features and inferior survival outcomes, remaining an independent prognostic factor when controlling for stage. Incorporating NPS into clinical risk stratification may help identify TGCT patients at higher risk of treatment failure, though prospective studies are warranted to validate its utility.</p>","PeriodicalId":23414,"journal":{"name":"Urologia Internationalis","volume":" ","pages":"1-8"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Prognostic Role of the Naples Prognostic Score in Testicular Germ Cell Tumors: A Retrospective Analysis.\",\"authors\":\"Hakan Tekinaslan, Osman Köse, Serkan Ozcan, Sacit Nuri Görgel, Yigit Akin\",\"doi\":\"10.1159/000548383\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>The aim of this study was to evaluate the prognostic significance of the Naples Prognostic Score (NPS) in testicular germ cell tumors (TGCT), with a focus on its association with tumor stage, histological subtype, and survival outcomes.</p><p><strong>Methods: </strong>In this retrospective study, 133 patients with TGCT treated at a single tertiary center between 2015 and 2023 were evaluated. The NPS was calculated for each patient based on pre-treatment albumin, cholesterol, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR). Patients were stratified into low (0-2) and high (3-4) NPS groups. Clinicopathological characteristics were compared between NPS groups. Overall survival was analyzed using Kaplan-Meier estimates with log-rank tests, and Cox proportional hazards regression was performed to identify independent prognostic factors.</p><p><strong>Results: </strong>Patients with high NPS were significantly younger on average and more likely to have non-seminomatous histology, advanced clinical stage, elevated tumor markers, and metastatic disease compared to those with low NPS (all p < 0.01). Overall survival was markedly worse in the high NPS group (p < 0.005). On multivariate analysis, NPS emerged as an independent predictor of poorer overall survival alongside clinical stage (hazard ratio for high NPS ∼ 8.4, p = 0.018).</p><p><strong>Conclusion: </strong>The NPS is a significant prognostic indicator in TGCT. A high NPS is associated with aggressive disease features and inferior survival outcomes, remaining an independent prognostic factor when controlling for stage. Incorporating NPS into clinical risk stratification may help identify TGCT patients at higher risk of treatment failure, though prospective studies are warranted to validate its utility.</p>\",\"PeriodicalId\":23414,\"journal\":{\"name\":\"Urologia Internationalis\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Urologia Internationalis\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000548383\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Urologia Internationalis","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000548383","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
The Prognostic Role of the Naples Prognostic Score in Testicular Germ Cell Tumors: A Retrospective Analysis.
Introduction: The aim of this study was to evaluate the prognostic significance of the Naples Prognostic Score (NPS) in testicular germ cell tumors (TGCT), with a focus on its association with tumor stage, histological subtype, and survival outcomes.
Methods: In this retrospective study, 133 patients with TGCT treated at a single tertiary center between 2015 and 2023 were evaluated. The NPS was calculated for each patient based on pre-treatment albumin, cholesterol, neutrophil-to-lymphocyte ratio (NLR), and lymphocyte-to-monocyte ratio (LMR). Patients were stratified into low (0-2) and high (3-4) NPS groups. Clinicopathological characteristics were compared between NPS groups. Overall survival was analyzed using Kaplan-Meier estimates with log-rank tests, and Cox proportional hazards regression was performed to identify independent prognostic factors.
Results: Patients with high NPS were significantly younger on average and more likely to have non-seminomatous histology, advanced clinical stage, elevated tumor markers, and metastatic disease compared to those with low NPS (all p < 0.01). Overall survival was markedly worse in the high NPS group (p < 0.005). On multivariate analysis, NPS emerged as an independent predictor of poorer overall survival alongside clinical stage (hazard ratio for high NPS ∼ 8.4, p = 0.018).
Conclusion: The NPS is a significant prognostic indicator in TGCT. A high NPS is associated with aggressive disease features and inferior survival outcomes, remaining an independent prognostic factor when controlling for stage. Incorporating NPS into clinical risk stratification may help identify TGCT patients at higher risk of treatment failure, though prospective studies are warranted to validate its utility.
期刊介绍：
Concise but fully substantiated international reports of clinically oriented research into science and current management of urogenital disorders form the nucleus of original as well as basic research papers. These are supplemented by up-to-date reviews by international experts on the state-of-the-art of key topics of clinical urological practice. Essential topics receiving regular coverage include the introduction of new techniques and instrumentation as well as the evaluation of new functional tests and diagnostic methods. Special attention is given to advances in surgical techniques and clinical oncology. The regular publication of selected case reports represents the great variation in urological disease and illustrates treatment solutions in singular cases.
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