海海绵中免疫抑制倍半萜酚类物质。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-09-13 DOI:10.1080/10286020.2025.2558639

Bo Hu, Hai-Yan Chen, Zhe Ning, Xin-Yuan Wang, Xiao-Ling Lu, Hao-Bing Yu

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引用次数: 0

摘要

从中国南海的elegans长趾海绵中分离到两种新的倍半萜酚类化合物：短趾酮A(1)和短趾酮B(2)。通过综合光谱分析（包括NMR和hresms）结合实验和计算的电子圆二色性（ECD）数据对它们的结构进行了阐明。值得注意的是，在海洋海绵衍生的倍半萜酚的A环上观察到的C-2羰基化代表了一种罕见的结构特征。生物学评价表明，这两种化合物都具有选择性免疫抑制活性，特异性抑制cona诱导的t细胞增殖，其IC50值分别为6.53 μM和9.85 μM，而在测试浓度下没有明显的抗菌或细胞毒作用。

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Immunosuppressive sesquiterpene phenols from the marine sponge Dactylospongia elegans.

Two new sesquiterpene phenols, dactyltone A (1) and dactyltone B (2), were isolated from the marine sponge Dactylospongia elegans collected from the South China Sea. Their structures were elucidated by comprehensive spectroscopic analysis (including NMR and HRESIMS) combined with experimental and calculated electronic circular dichroism (ECD) data. Notably, the carbonylation at C-2 observed in ring A of marine sponge-derived sesquiterpene phenols represents an uncommon structural feature. Biological evaluation revealed that both compounds showed selective immunosuppressive activity, specifically inhibiting ConA-induced T-cell proliferation with IC₅₀ values of 6.53 μM and 9.85 μM for 1 and 2, respectively, while demonstrating no significant antibacterial or cytotoxic effects at tested concentrations.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.