Prakash K. Mandal, Md Tanjul Hoque, Dr. Anindya S. Manna, Dr. Ramlal Baidya, Dr. Rajesh Nandi, Dr. Subhasis Pal, Dr. Nilay Karchaudhuri, Dr. Dilip K. Maiti
{"title":"聚焦非贵金属催化:通过C─H/C─X活化解锁酰胺环化的最新前沿","authors":"Prakash K. Mandal, Md Tanjul Hoque, Dr. Anindya S. Manna, Dr. Ramlal Baidya, Dr. Rajesh Nandi, Dr. Subhasis Pal, Dr. Nilay Karchaudhuri, Dr. Dilip K. Maiti","doi":"10.1002/ajoc.202500478","DOIUrl":null,"url":null,"abstract":"<p>The non-noble metal-catalyzed annulation of amide molecules through the proximal C─H/C─X (X = halogens, O, S, N, C etc.) has emerged as a transformative approach in contemporary synthetic chemistry, enabling the efficient construction of diverse heterocyclic frameworks. This sustainable strategies address the limitations of noble metal catalysis, offering cost-effective and environmentally benign alternatives through utilizing earth-abundant metals such as Mn, Fe, Co, Ni, and Cu in those methods by harnessing their catalytic potential for activating inert bonds in diverse amides leveraging the inherent directing ability. By incorporating various electrophilic or nucleophilic coupling partners wisely, nonmetal catalysis has provided access toward pharmaceutically active heterocyclic ingredients, mainly spiro-/fused-N-heterocycles like isoquinolones, indolones, indoles, isoquinolines etc. through one-pot atom-economical activation-annulation cascade routes. Additionally, mechanistic studies have discussed in detail to understand the insights of non-noble metal catalyzed amide cyclization toward pharmaceutically active N-heterocyclic scaffolds properly through the individual steps engaged, namely, metal coordination, inert bond activation, bond cleavage, insertion or migratory insertion and eventually cyclization pathway via reductive elimination, which enables this review more valuable and useful to the readers of the aforementioned field and beyond.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Non-Noble Metal Catalysis in Focus: Unlocking Latest Emergent Frontiers in Amide Annulation Through C─H/C─X Activation\",\"authors\":\"Prakash K. Mandal, Md Tanjul Hoque, Dr. Anindya S. Manna, Dr. Ramlal Baidya, Dr. Rajesh Nandi, Dr. Subhasis Pal, Dr. Nilay Karchaudhuri, Dr. Dilip K. Maiti\",\"doi\":\"10.1002/ajoc.202500478\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The non-noble metal-catalyzed annulation of amide molecules through the proximal C─H/C─X (X = halogens, O, S, N, C etc.) has emerged as a transformative approach in contemporary synthetic chemistry, enabling the efficient construction of diverse heterocyclic frameworks. This sustainable strategies address the limitations of noble metal catalysis, offering cost-effective and environmentally benign alternatives through utilizing earth-abundant metals such as Mn, Fe, Co, Ni, and Cu in those methods by harnessing their catalytic potential for activating inert bonds in diverse amides leveraging the inherent directing ability. By incorporating various electrophilic or nucleophilic coupling partners wisely, nonmetal catalysis has provided access toward pharmaceutically active heterocyclic ingredients, mainly spiro-/fused-N-heterocycles like isoquinolones, indolones, indoles, isoquinolines etc. through one-pot atom-economical activation-annulation cascade routes. 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Non-Noble Metal Catalysis in Focus: Unlocking Latest Emergent Frontiers in Amide Annulation Through C─H/C─X Activation
The non-noble metal-catalyzed annulation of amide molecules through the proximal C─H/C─X (X = halogens, O, S, N, C etc.) has emerged as a transformative approach in contemporary synthetic chemistry, enabling the efficient construction of diverse heterocyclic frameworks. This sustainable strategies address the limitations of noble metal catalysis, offering cost-effective and environmentally benign alternatives through utilizing earth-abundant metals such as Mn, Fe, Co, Ni, and Cu in those methods by harnessing their catalytic potential for activating inert bonds in diverse amides leveraging the inherent directing ability. By incorporating various electrophilic or nucleophilic coupling partners wisely, nonmetal catalysis has provided access toward pharmaceutically active heterocyclic ingredients, mainly spiro-/fused-N-heterocycles like isoquinolones, indolones, indoles, isoquinolines etc. through one-pot atom-economical activation-annulation cascade routes. Additionally, mechanistic studies have discussed in detail to understand the insights of non-noble metal catalyzed amide cyclization toward pharmaceutically active N-heterocyclic scaffolds properly through the individual steps engaged, namely, metal coordination, inert bond activation, bond cleavage, insertion or migratory insertion and eventually cyclization pathway via reductive elimination, which enables this review more valuable and useful to the readers of the aforementioned field and beyond.
期刊介绍:
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.