可见光诱导β-羟基硫化物与烯烃和硫代磺酸盐的三组分组装

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-14 DOI:10.1002/ajoc.202500532

Renhua Su, Dr. Jiantao Zhang, Yanfu Jiang, Xian Jiang, Dr. Peng Zhou, Dr. Hailing Liu, Prof. Dr. Weibing Liu

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引用次数: 0

摘要

提出了一种利用可见光诱导的烯烃与硫代磺酸盐自由基反应合成β-羟基硫化物衍生物的方法。该方法为同时结合Csp3─O和Csp3─S键提供了一种方便和环保的途径，以令人满意的收率提供了有价值的含硫多功能化烷烃衍生物。此外，该方案的实用性体现在一些药学上相关分子的后期修饰，如氟比洛芬、奥沙普嗪、非布司他和布洛芬。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-Light-Induced Three-Component Assembly of β-Hydroxysulfides with Alkenes and Thiosulfonates

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Visible-Light-Induced Three-Component Assembly of β-Hydroxysulfides with Alkenes and Thiosulfonates

A strategy for the synthesis of β-hydroxysulfide derivatives via a visible-light-induced radical reaction of alkenes with thiosulfonates has been developed. The approach offers a convenient and environmentally friendly route for the simultaneous incorporation of Csp³─O and Csp³─S bonds, affording valuable polyfunctionalized alkane derivatives containing sulfur in satisfactory yields. In addition, the utility of this protocol was manifested by the late-stage modification of several pharmaceutically relevant molecules, such as flurbiprofen, oxaprozin, febuxostat, and ibuprofen.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.