{"title":"硒二唑类化合物的合成及其反应性研究进展","authors":"Abdul Qaiyum Ramle, Edward R.T. Tiekink","doi":"10.1002/ajoc.202500577","DOIUrl":null,"url":null,"abstract":"<p>The four isomeric selenadiazoles comprise five-membered SeN<sub>2</sub>C<sub>2</sub> heterocyclic rings and represent a prominent class of organoselenium scaffolds that have received considerable attention in recent years owing to their notable applications in medicinal and materials chemistry. To explore their functionalities, several synthetic methodologies have been developed to diversify these scaffolds with a range of substituents. Cyclization reactions remain the most prevalent approach by employing substituted hydrazines, selonamides, cyano nitriles, and amines under versatile reaction conditions and reagents. This review presents an overview of the strategies reported over the past decade for accessing the four isomeric forms of selenadiazole. The synthetic scope, functionalization and reactivity of the reactions are discussed. Additionally, the non-covalent chalcogen- and halogen-bonding interactions of selected derivatives are reviewed, when present.</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advances in the Synthesis and Reactivity of Selenadiazoles\",\"authors\":\"Abdul Qaiyum Ramle, Edward R.T. Tiekink\",\"doi\":\"10.1002/ajoc.202500577\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>The four isomeric selenadiazoles comprise five-membered SeN<sub>2</sub>C<sub>2</sub> heterocyclic rings and represent a prominent class of organoselenium scaffolds that have received considerable attention in recent years owing to their notable applications in medicinal and materials chemistry. To explore their functionalities, several synthetic methodologies have been developed to diversify these scaffolds with a range of substituents. Cyclization reactions remain the most prevalent approach by employing substituted hydrazines, selonamides, cyano nitriles, and amines under versatile reaction conditions and reagents. This review presents an overview of the strategies reported over the past decade for accessing the four isomeric forms of selenadiazole. The synthetic scope, functionalization and reactivity of the reactions are discussed. Additionally, the non-covalent chalcogen- and halogen-bonding interactions of selected derivatives are reviewed, when present.</p>\",\"PeriodicalId\":130,\"journal\":{\"name\":\"Asian Journal of Organic Chemistry\",\"volume\":\"14 9\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202500577\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202500577","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Advances in the Synthesis and Reactivity of Selenadiazoles
The four isomeric selenadiazoles comprise five-membered SeN2C2 heterocyclic rings and represent a prominent class of organoselenium scaffolds that have received considerable attention in recent years owing to their notable applications in medicinal and materials chemistry. To explore their functionalities, several synthetic methodologies have been developed to diversify these scaffolds with a range of substituents. Cyclization reactions remain the most prevalent approach by employing substituted hydrazines, selonamides, cyano nitriles, and amines under versatile reaction conditions and reagents. This review presents an overview of the strategies reported over the past decade for accessing the four isomeric forms of selenadiazole. The synthetic scope, functionalization and reactivity of the reactions are discussed. Additionally, the non-covalent chalcogen- and halogen-bonding interactions of selected derivatives are reviewed, when present.
期刊介绍:
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.