温和条件下k2s2o8促进咪唑[1,2-a]吡啶C-3位直接加氢和亚硝化反应

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-11 DOI:10.1002/ajoc.202500508

Surya Kanta Samanta, Rumpa Sarkar, Biman Bera, Mrinal K. Bera

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引用次数: 0

摘要

k2s2o8促进了一种高效的区域选择性加硫（S和Se）的方法，并在无金属条件下使用二有机二硫代化合物、硫醇和亚硝酸钠在C-3位置实现了咪唑[1,2-a]吡啶的亚硝化。该方法以K2S2O8为氧化剂，通过sp2 C─H官能化直接获得结构多样的硫代和亚硝基咪唑吡啶，收率很高。该反应具有操作简单、区域选择性好、原子经济性高、环境条件好等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

K2S2O8-Promoted Direct Chalcogenation and Nitrosation at C-3 Position of Imidazo[1,2-a]pyridines Under Mild Conditions

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K2S2O8-Promoted Direct Chalcogenation and Nitrosation at C-3 Position of Imidazo[1,2-a]pyridines Under Mild Conditions

K₂S₂O₈-promoted an efficient method for regioselective chalcogenation (S and Se), and nitrosation of imidazo[1,2-a]pyridines at C-3 position was achieved using diorganoyl dichalcogenides, thiols, and sodium nitrite under metal-free conditions. This approach provides direct access to structurally diverse chalcogenated and nitroso imidazopyridines through sp² C─H functionalization in good to excellent yield by using K₂S₂O₈ as an oxidant. The operational simplicity, good regioselectivity, high atom economy, and use of ambient conditions are the attractive features of the reaction.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.