{"title":"光氧化还原催化直接C(sp3)─H硫基化与二硫化物","authors":"Junsong Song, Mengqin Tao, Honghua Jia, Jiang-Kai Qiu, Jian Wang, Canliang Ma, Kai Guo","doi":"10.1002/ajoc.202500252","DOIUrl":null,"url":null,"abstract":"<p>Organosulfur compounds hold significant application value in fields such as medicine and materials science. However, due to the poisoning effect of sulfur on metal catalysts, the development of methods for constructing C-S bonds has notably lagged behind strategies for synthesizing other carbon-heteroatom bonds. This study reports a photoinduced C-H direct functionalization strategy that enables the construction of C-S bonds with disulfides under mild conditions. The reaction system exhibits excellent substrate compatibility, with a variety of ethers, allylic compounds, amides containing C(sp<sup>3</sup>)-H bonds, as well as alkyl and aryl disulfides participating efficiently in the reaction. This synthetic method offers significant advantages: broad substrate scope, mild reaction conditions, and high atom economy, providing an efficient and convenient new approach for the synthesis of thioether compounds.\n</p>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 9","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Direct C(sp3)─H Thiolation with Disulfides via Light Photoredox Catalysis\",\"authors\":\"Junsong Song, Mengqin Tao, Honghua Jia, Jiang-Kai Qiu, Jian Wang, Canliang Ma, Kai Guo\",\"doi\":\"10.1002/ajoc.202500252\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Organosulfur compounds hold significant application value in fields such as medicine and materials science. However, due to the poisoning effect of sulfur on metal catalysts, the development of methods for constructing C-S bonds has notably lagged behind strategies for synthesizing other carbon-heteroatom bonds. This study reports a photoinduced C-H direct functionalization strategy that enables the construction of C-S bonds with disulfides under mild conditions. The reaction system exhibits excellent substrate compatibility, with a variety of ethers, allylic compounds, amides containing C(sp<sup>3</sup>)-H bonds, as well as alkyl and aryl disulfides participating efficiently in the reaction. This synthetic method offers significant advantages: broad substrate scope, mild reaction conditions, and high atom economy, providing an efficient and convenient new approach for the synthesis of thioether compounds.\\n</p>\",\"PeriodicalId\":130,\"journal\":{\"name\":\"Asian Journal of Organic Chemistry\",\"volume\":\"14 9\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202500252\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.202500252","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Direct C(sp3)─H Thiolation with Disulfides via Light Photoredox Catalysis
Organosulfur compounds hold significant application value in fields such as medicine and materials science. However, due to the poisoning effect of sulfur on metal catalysts, the development of methods for constructing C-S bonds has notably lagged behind strategies for synthesizing other carbon-heteroatom bonds. This study reports a photoinduced C-H direct functionalization strategy that enables the construction of C-S bonds with disulfides under mild conditions. The reaction system exhibits excellent substrate compatibility, with a variety of ethers, allylic compounds, amides containing C(sp3)-H bonds, as well as alkyl and aryl disulfides participating efficiently in the reaction. This synthetic method offers significant advantages: broad substrate scope, mild reaction conditions, and high atom economy, providing an efficient and convenient new approach for the synthesis of thioether compounds.
期刊介绍:
Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC)
The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.