光氧化还原催化直接C(sp3)─H硫基化与二硫化物

IF 2.7 4区 化学 Q1 CHEMISTRY, ORGANIC
Junsong Song, Mengqin Tao, Honghua Jia, Jiang-Kai Qiu, Jian Wang, Canliang Ma, Kai Guo
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引用次数: 0

摘要

有机硫化合物在医学和材料科学等领域具有重要的应用价值。然而,由于硫对金属催化剂的中毒作用,构建C-S键的方法的发展明显滞后于其他碳杂原子键的合成策略。本研究报道了一种光诱导C-H直接功能化策略,该策略能够在温和条件下与二硫化物构建C-S键。该反应体系具有良好的底物相容性,多种醚、烯丙基化合物、含C(sp3)-H键的酰胺以及烷基和芳基二硫化物均能有效参与反应。该合成方法具有底物范围广、反应条件温和、原子经济性高等优点,为合成硫醚类化合物提供了一种高效、便捷的新途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Direct C(sp3)─H Thiolation with Disulfides via Light Photoredox Catalysis

Direct C(sp3)─H Thiolation with Disulfides via Light Photoredox Catalysis

Direct C(sp3)─H Thiolation with Disulfides via Light Photoredox Catalysis

Direct C(sp3)─H Thiolation with Disulfides via Light Photoredox Catalysis

Organosulfur compounds hold significant application value in fields such as medicine and materials science. However, due to the poisoning effect of sulfur on metal catalysts, the development of methods for constructing C-S bonds has notably lagged behind strategies for synthesizing other carbon-heteroatom bonds. This study reports a photoinduced C-H direct functionalization strategy that enables the construction of C-S bonds with disulfides under mild conditions. The reaction system exhibits excellent substrate compatibility, with a variety of ethers, allylic compounds, amides containing C(sp3)-H bonds, as well as alkyl and aryl disulfides participating efficiently in the reaction. This synthetic method offers significant advantages: broad substrate scope, mild reaction conditions, and high atom economy, providing an efficient and convenient new approach for the synthesis of thioether compounds.

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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
372
期刊介绍: Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.
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