利用[4 + 2]环加成法在3-氨基-2-吡酮和苯之间合成1-萘胺

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-21 DOI:10.1002/ajoc.202500533

Atsuya Kawazoe, Masaki Shiraishi, Prof. Dr. Iwao Hachiya

引用次数: 0

摘要

以2-氨基丙二酸二乙酯与炔基酮的共轭加成反应制备的3-氨基-2-吡酮与三氟化硅丙烯酯合成的苯为原料，采用[4 + 2]环加成法合成1-萘胺。该合成策略成功地应用于碘萘、萘酰亚胺和苯并[a]咔唑衍生物的合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of 1-Naphthylamines Utilizing [4 + 2] Cycloaddition Between 3-Amino-2-pyrones and Benzynes

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Synthesis of 1-Naphthylamines Utilizing [4 + 2] Cycloaddition Between 3-Amino-2-pyrones and Benzynes

Synthesis of 1-naphthylamines is developed using [4 + 2] cycloaddition between 3-amino-2-pyrone, which is prepared by the conjugate addition reaction of diethyl 2-aminomalonate to alkynyl ketones, and benzyne generated from o-silylaryl triflates. This synthetic strategy was successfully applied to the syntheses of iodonaphthalene, naphthylimide, and benzo[a]carbazole derivatives.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.