汉氏酯光氧化还原催化（杂）芳烃直接C─H芳化反应

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-15 DOI:10.1002/ajoc.202500595

Dr. Da-Liang Zhu, Zixi Wu, Liuyan Zang, Prof. Dr. David James Young, Prof. Dr. Yanqing Wang, Prof. Dr. Hong-Xi Li

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引用次数: 0

摘要

采用2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二乙酯（HEH）作为光氧化还原催化剂，在不牺牲还原剂的情况下，建立了一种可见光引发非活化芳烃和n -甲基吡咯与芳基卤化物直接C─H芳基化反应的有效方法。该反应设计使得在HE−光激发下芳基卤化物的单电子还原成为可能，并且生成的芳基自由基发生芳基-（杂）芳基交叉偶联。这种转化可以耐受广泛的官能团，便于在克尺度上进行，并且适用于复杂分子的后期功能化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Direct C─H Arylation of (Hetero)arenes Using Hantzsch Ester as a Photoredox Catalyst

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Direct C─H Arylation of (Hetero)arenes Using Hantzsch Ester as a Photoredox Catalyst

An efficient method for visible-light-initiated direct C─H arylation of unactivated arenes and N-methylpyrrole with aryl halides using diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (HEH) as a photoredox catalyst without a sacrificial reductant has been developed. The reaction design enables single-electron reduction of aryl halides upon the photoexcitation of HE⁻, and the resulting aryl radicals undergo aryl-(hetero)aryl cross-coupling. This transformation tolerates a wide range of functional groups, is convenient to perform on a gram scale, and is suitable for late-stage functionalization of complex molecules.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.