Brønsted酸催化n -杂环氢胺化制非活化烯烃

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-17 DOI:10.1002/ajoc.202500579

Guanzheng Feng, Yisan Shen, Chenghui Sun, Weixiao Ji, He Huang, Siping Pang

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引用次数: 0

摘要

Brønsted酸催化未活化烯烃的氢胺化反应，实现了烯烃中氮杂环的马尔可夫尼科夫加成反应。该反应利用催化量的三氟乙酸（TFA）产生多种n -烷基氮杂环。该方法具有高度可扩展性，允许多重图合成，并且已经确定了一种涉及烯烃活化的新型质子转移物质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Brønsted Acid-Catalyzed Hydroamination of N-Heterocycles to Unactivated Alkenes

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Brønsted Acid-Catalyzed Hydroamination of N-Heterocycles to Unactivated Alkenes

A Brønsted acid-catalyzed hydroamination of unactivated olefins has been developed, enabling the efficient Markovnikov addition of nitrogen heterocycles to olefins. This reaction utilizes a catalytic amount of trifluoroacetic acid (TFA) to produce a diverse array of N-alkyl nitrogen heterocycles. The method is highly scalable, allowing for multigram synthesis, and a novel proton transfer species implicated in olefin activation has been identified.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.