埃塞俄比亚北部提格雷地区乙型肝炎病毒感染的流行及相关因素

IF 2.3 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Gessessew Bugssa, Tilahun Teklehaymanot, Girmay Medhin, Shevanti Nayagam, Asgeir Johannessen, Nega Berhe
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引用次数: 0

摘要

乙型肝炎病毒(HBV)感染是一个重大的公共卫生问题,特别是在低收入国家。本研究调查了埃塞俄比亚北部Tigray地区Alamata地区HBV的流行情况和相关危险因素,该地区于2007年在儿童疫苗接种规划中引入了HBV疫苗。2019年12月至2020年6月进行了一项基于社区的横断面研究。采用结构化问卷收集数据,并采用快速诊断试验测定乙型肝炎表面抗原(HBsAg)。使用逻辑回归分析来确定社会人口统计学、行为和健康相关变量与HBV感染之间的关联。本研究共纳入1853只个体,其中雌性54.2%。年龄在5 ~ 88岁之间,以5 ~ 14岁年龄组最多(32.0%)。总体HBV患病率为5.3%(95%可信区间(CI) 4.3-6.3),年龄组间差异显著:5-14岁3.7%,15-24岁6.8%,25-34岁10.1%,35-44岁4.4%,45-54岁3.9%,55岁及以上3.4%。25-34岁年龄组(调整优势比(AOR) 4.1, 95% CI: 1.1-16.2, P= 0.042)、多个性伴侣(AOR 4.0, 95% CI: 1.02-15.4, P= 0.047)和乙型肝炎家族史(AOR 3.1, 95% CI: 1.2-8.2, P= 0.024)与HBV感染独立相关。该地区乙型肝炎病毒感染率很高,强调有必要制定旨在降低传播率的有针对性的公共卫生战略。值得注意的是,在接种乙肝疫苗后出生的儿童中,乙肝病毒的流行率明显较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence and Factors Associated With Hepatitis B Virus Infection in Tigray Region, Northern Ethiopia

Hepatitis B virus (HBV) infection is a significant public health concern, particularly in low-income countries. This study investigates the prevalence and associated risk factors of HBV in Alamata district of Tigray region, northern Ethiopia, where the HBV vaccine was introduced in the childhood vaccination programme in 2007. A community-based, cross-sectional study was conducted from December 2019 to June 2020. Data were collected using structured questionnaires and hepatitis B surface antigen (HBsAg) was measured using a rapid diagnostic test. Logistic regression analyses were used to determine the associations between socio-demographic, behavioural and health-related variables and HBV infection. A total of 1853 individuals (54.2% females) were included in this study. The age ranged from 5 to 88 years, and the largest age group was from 5 to 14 years (32.0%). The overall HBV prevalence was 5.3% (95% confidence interval (CI) 4.3–6.3) with significant variability between age groups: 5–14 years 3.7%, 15–24 years 6.8%, 25–34 years 10.1%, 35–44 years 4.4%, 45–54 years 3.9% and 55 years and above 3.4%. Being in the 25–34 years age group (adjusted odds ratio (AOR) 4.1, 95% CI: 1.1–16.2, P= 0.042), reporting multiple sexual partners (AOR 4.0, 95% CI: 1.02–15.4, P= 0.047) and family history of hepatitis B (AOR 3.1, 95% CI: 1.2–8.2, P= 0.024) were independently associated with HBV infection. The prevalence of HBV infection was high in this region, underscoring the necessity for targeted public health strategies aimed at reducing transmission rates. Of note, the HBV prevalence was significantly lower among children born after the introduction of the HBV vaccine.

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来源期刊
Journal of Viral Hepatitis
Journal of Viral Hepatitis 医学-病毒学
CiteScore
6.00
自引率
8.00%
发文量
138
审稿时长
1.5 months
期刊介绍: The Journal of Viral Hepatitis publishes reviews, original work (full papers) and short, rapid communications in the area of viral hepatitis. It solicits these articles from epidemiologists, clinicians, pathologists, virologists and specialists in transfusion medicine working in the field, thereby bringing together in a single journal the important issues in this expanding speciality. The Journal of Viral Hepatitis is a monthly journal, publishing reviews, original work (full papers) and short rapid communications in the area of viral hepatitis. It brings together in a single journal important issues in this rapidly expanding speciality including articles from: virologists; epidemiologists; clinicians; pathologists; specialists in transfusion medicine.
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