光氧化还原催化n -氰酰胺烯烃二氟甲基化/环化制备二氟甲基化多环喹唑啉酮

IF 2.7 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-07-09 DOI:10.1002/ajoc.202500591

Shilong Zhang, Prof. Jinwei Yuan, Prof. Meng Yan, Zhiyi Wang, Prof. Liangru Yang, Prof. Yongmei Xiao, Prof. Shouren Zhang, Prof. Lingbo Qu

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引用次数: 0

摘要

建立了一种高效的光诱导n -氰酰胺烯烃自由基级联二氟甲基化/环化反应。合成了多种二氟甲基化喹唑啉酮，收率高，官能团耐受性广。这种光催化协议提供了一种方便和实用的方法来获得有价值的多环喹唑啉酮衍生物。初步的机制研究表明，这种转变是通过一个涉及单电子转移（SET）的自由基途径进行的。

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Photoredox-Catalyzed Difluoromethylation/Cyclization of N-Cyanamide Alkenes to Access Difluoromethylated Polycyclic Quinazolinones

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Photoredox-Catalyzed Difluoromethylation/Cyclization of N-Cyanamide Alkenes to Access Difluoromethylated Polycyclic Quinazolinones

An efficient photoinduced radical cascade difluoromethylation/cyclization reaction of N-cyanamide alkenes has been developed. A diverse range of difluoromethylated quinazolinones have been synthesized with good yields and broad functional group tolerance. This photocatalytic protocol offers a facile and practical approach to accessing valuable polycyclic quinazolinone derivatives. Preliminary mechanistic studies suggest that the transformation proceeds via a radical pathway involving single electron transfer (SET).

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.