{"title":"一种多癌超材料生物传感器：基于折射率的恶性细胞识别","authors":"Nedjmeddine Mellak, Bouchra Moulfi, Tahar Aliouar","doi":"10.1007/s11082-025-08436-1","DOIUrl":null,"url":null,"abstract":"<div><p>This research introduces a novel biosensor based on terahertz (THz) metamaterials, aimed at highly sensitive, label-free, and non-invasive detection of cancer. Utilizing the distinctive characteristics of THz metamaterials, the biosensor examines the variations in the refractive index of biological samples, offering an accurate instrument for early cancer diagnosis. The biosensor achieves impressive functionality with a sensitivity of 892 GHz/RIU, a quality factor (Q) of 57.7, and a figure of merit of 18.98 RIU<sup>−1</sup>, and operates at a resonance frequency of 2.688 THz. With a groundbreaking design refined through the full finite element method, the sensor exhibits an absorption rate of 98% and can effectively identify subtle changes in the refractive index linked to several cancer types, such as Jurkat blood, HeLa cervical, PC-12 adrenal gland, MDA-MB-231 and MCF-7 breast cancers, along with basal skin cancer. This biosensor marks a significant leap forward in THz-based medical diagnostics, providing a compact, lab-on-chip compatible unit for swift, dependable, and early cancer detection at the cellular scale.</p></div>","PeriodicalId":720,"journal":{"name":"Optical and Quantum Electronics","volume":"57 9","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A multi-cancer metamaterial biosensor: refractive index-based identification of malignant cells\",\"authors\":\"Nedjmeddine Mellak, Bouchra Moulfi, Tahar Aliouar\",\"doi\":\"10.1007/s11082-025-08436-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This research introduces a novel biosensor based on terahertz (THz) metamaterials, aimed at highly sensitive, label-free, and non-invasive detection of cancer. Utilizing the distinctive characteristics of THz metamaterials, the biosensor examines the variations in the refractive index of biological samples, offering an accurate instrument for early cancer diagnosis. The biosensor achieves impressive functionality with a sensitivity of 892 GHz/RIU, a quality factor (Q) of 57.7, and a figure of merit of 18.98 RIU<sup>−1</sup>, and operates at a resonance frequency of 2.688 THz. With a groundbreaking design refined through the full finite element method, the sensor exhibits an absorption rate of 98% and can effectively identify subtle changes in the refractive index linked to several cancer types, such as Jurkat blood, HeLa cervical, PC-12 adrenal gland, MDA-MB-231 and MCF-7 breast cancers, along with basal skin cancer. This biosensor marks a significant leap forward in THz-based medical diagnostics, providing a compact, lab-on-chip compatible unit for swift, dependable, and early cancer detection at the cellular scale.</p></div>\",\"PeriodicalId\":720,\"journal\":{\"name\":\"Optical and Quantum Electronics\",\"volume\":\"57 9\",\"pages\":\"\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-09-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Optical and Quantum Electronics\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s11082-025-08436-1\",\"RegionNum\":3,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENGINEERING, ELECTRICAL & ELECTRONIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Optical and Quantum Electronics","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s11082-025-08436-1","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, ELECTRICAL & ELECTRONIC","Score":null,"Total":0}
A multi-cancer metamaterial biosensor: refractive index-based identification of malignant cells
This research introduces a novel biosensor based on terahertz (THz) metamaterials, aimed at highly sensitive, label-free, and non-invasive detection of cancer. Utilizing the distinctive characteristics of THz metamaterials, the biosensor examines the variations in the refractive index of biological samples, offering an accurate instrument for early cancer diagnosis. The biosensor achieves impressive functionality with a sensitivity of 892 GHz/RIU, a quality factor (Q) of 57.7, and a figure of merit of 18.98 RIU−1, and operates at a resonance frequency of 2.688 THz. With a groundbreaking design refined through the full finite element method, the sensor exhibits an absorption rate of 98% and can effectively identify subtle changes in the refractive index linked to several cancer types, such as Jurkat blood, HeLa cervical, PC-12 adrenal gland, MDA-MB-231 and MCF-7 breast cancers, along with basal skin cancer. This biosensor marks a significant leap forward in THz-based medical diagnostics, providing a compact, lab-on-chip compatible unit for swift, dependable, and early cancer detection at the cellular scale.
期刊介绍：
Optical and Quantum Electronics provides an international forum for the publication of original research papers, tutorial reviews and letters in such fields as optical physics, optical engineering and optoelectronics. Special issues are published on topics of current interest.
Optical and Quantum Electronics is published monthly. It is concerned with the technology and physics of optical systems, components and devices, i.e., with topics such as: optical fibres; semiconductor lasers and LEDs; light detection and imaging devices; nanophotonics; photonic integration and optoelectronic integrated circuits; silicon photonics; displays; optical communications from devices to systems; materials for photonics (e.g. semiconductors, glasses, graphene); the physics and simulation of optical devices and systems; nanotechnologies in photonics (including engineered nano-structures such as photonic crystals, sub-wavelength photonic structures, metamaterials, and plasmonics); advanced quantum and optoelectronic applications (e.g. quantum computing, memory and communications, quantum sensing and quantum dots); photonic sensors and bio-sensors; Terahertz phenomena; non-linear optics and ultrafast phenomena; green photonics.
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