NAD(H)自循环全细胞生物催化CO2固定糠醛制取呋喃酸和2,5-呋喃二甲酸

IF 9.2 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Green Chemistry Pub Date : 2025-08-14 DOI:10.1039/D5GC03156G

Mingzhe Ma and Yajie Wang

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引用次数: 0

摘要

2,5-呋喃二羧酸（FDCA）是一种用于聚合物生产的生物基化学品。在此，我们开发了一个NAD(H)自循环全细胞催化系统，用于通过CO2固定将糠醛（FFA）转化为FDCA。设计prfmn依赖的UbiD酶（HmfF）将其羧化活性提高了13.5倍，实现了35%的FDCA产率。技术经济分析（TEA）和生命周期评价（LCA）证实了该工艺的工业可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

NAD(H) self-recycling whole-cell biocatalysis for the production of furoic acid and 2,5-furandicarboxylic acid from furfural via CO2 fixation

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NAD(H) self-recycling whole-cell biocatalysis for the production of furoic acid and 2,5-furandicarboxylic acid from furfural via CO2 fixation

2,5-Furandicarboxylic acid (FDCA) is a biobased chemical for polymer production. Herein, we developed an NAD(H) self-recycling whole-cell catalytic system for one-pot conversion of furfural (FFA) to FDCA via CO₂ fixation. Engineering the prFMN-dependent UbiD enzyme (HmfF) enhanced its carboxylation activity by 13.5 fold, achieving an FDCA yield of 35%. Techno-economic analysis (TEA) and life cycle assessment (LCA) confirmed the industrial viability of the process.

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来源期刊

Green Chemistry 化学-化学综合

CiteScore

16.10

自引率

7.10%

发文量

677

审稿时长

1.4 months

期刊介绍： Green Chemistry is a journal that provides a unique forum for the publication of innovative research on the development of alternative green and sustainable technologies. The scope of Green Chemistry is based on the definition proposed by Anastas and Warner (Green Chemistry: Theory and Practice, P T Anastas and J C Warner, Oxford University Press, Oxford, 1998), which defines green chemistry as the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green Chemistry aims to reduce the environmental impact of the chemical enterprise by developing a technology base that is inherently non-toxic to living things and the environment. The journal welcomes submissions on all aspects of research relating to this endeavor and publishes original and significant cutting-edge research that is likely to be of wide general appeal. For a work to be published, it must present a significant advance in green chemistry, including a comparison with existing methods and a demonstration of advantages over those methods.