{"title":"杀死雄性共生体的惊人多样性及其机制。","authors":"Hiroshi Arai, Toshiyuki Harumoto, Susumu Katsuma, Keisuke Nagamine, Daisuke Kageyama","doi":"10.1016/j.tig.2025.08.003","DOIUrl":null,"url":null,"abstract":"<p><p>Symbiosis is a fundamental characteristic of eukaryotic biology. Arthropods, including insects, often harbor maternally inherited endosymbiotic microbes, some of which have evolved the ability to selectively kill male hosts - a phenomenon known as 'male killing.' The evolutionary history and mechanisms of symbiont-induced male killing have remained poorly understood. However, recent studies have revealed a remarkable diversity of male-killing strategies and their associated causative genes in diverse bacteria and viruses that target different aspects of the host reproductive system. Some insects have evolved various suppressor genes to counteract male-killing actions. This review synthesizes the current knowledge on the evolution and mechanisms underlying microbe-induced male killing and explores their broader implications for the ecology and evolution of eukaryotic life forms.</p>","PeriodicalId":54413,"journal":{"name":"Trends in Genetics","volume":" ","pages":""},"PeriodicalIF":16.3000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Striking diversity of male-killing symbionts and their mechanisms.\",\"authors\":\"Hiroshi Arai, Toshiyuki Harumoto, Susumu Katsuma, Keisuke Nagamine, Daisuke Kageyama\",\"doi\":\"10.1016/j.tig.2025.08.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Symbiosis is a fundamental characteristic of eukaryotic biology. Arthropods, including insects, often harbor maternally inherited endosymbiotic microbes, some of which have evolved the ability to selectively kill male hosts - a phenomenon known as 'male killing.' The evolutionary history and mechanisms of symbiont-induced male killing have remained poorly understood. However, recent studies have revealed a remarkable diversity of male-killing strategies and their associated causative genes in diverse bacteria and viruses that target different aspects of the host reproductive system. Some insects have evolved various suppressor genes to counteract male-killing actions. This review synthesizes the current knowledge on the evolution and mechanisms underlying microbe-induced male killing and explores their broader implications for the ecology and evolution of eukaryotic life forms.</p>\",\"PeriodicalId\":54413,\"journal\":{\"name\":\"Trends in Genetics\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":16.3000,\"publicationDate\":\"2025-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Trends in Genetics\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1016/j.tig.2025.08.003\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.tig.2025.08.003","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Striking diversity of male-killing symbionts and their mechanisms.
Symbiosis is a fundamental characteristic of eukaryotic biology. Arthropods, including insects, often harbor maternally inherited endosymbiotic microbes, some of which have evolved the ability to selectively kill male hosts - a phenomenon known as 'male killing.' The evolutionary history and mechanisms of symbiont-induced male killing have remained poorly understood. However, recent studies have revealed a remarkable diversity of male-killing strategies and their associated causative genes in diverse bacteria and viruses that target different aspects of the host reproductive system. Some insects have evolved various suppressor genes to counteract male-killing actions. This review synthesizes the current knowledge on the evolution and mechanisms underlying microbe-induced male killing and explores their broader implications for the ecology and evolution of eukaryotic life forms.
期刊介绍:
Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology.
Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.