{"title":"尿生物标志物在犬围手术期急性肾损伤早期诊断中的应用综述","authors":"Jennifer Davis","doi":"10.1016/j.vaa.2025.08.036","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To provide the knowledge and context necessary for veterinary anaesthetists to appraise and design studies utilising biomarkers as outcome measures for acute kidney injury (AKI).</p><p><strong>Databases used: </strong>PubMed, Medline and CAB abstracts.</p><p><strong>Conclusions: </strong>The diagnosis of AKI in dogs currently relies upon markers of glomerular function that are delayed and not specific to the tubular structural injury present during anaesthesia-related AKI. Several urinary biomarkers of renal tubular dysfunction, notably neutrophil gelatinase-associated lipocalin, clusterin, cystatin B, cystatin C and γ-glutamyl transferase, show promise as very early markers of perioperative AKI in dogs. However, for their reliable and routine use, a larger evidence base is required in the setting of canine perioperative AKI and there is a need for standardisation of measurement and reporting methodology.</p>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Urinary biomarkers for early diagnosis of perioperative acute kidney injury in dogs: a narrative review.\",\"authors\":\"Jennifer Davis\",\"doi\":\"10.1016/j.vaa.2025.08.036\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To provide the knowledge and context necessary for veterinary anaesthetists to appraise and design studies utilising biomarkers as outcome measures for acute kidney injury (AKI).</p><p><strong>Databases used: </strong>PubMed, Medline and CAB abstracts.</p><p><strong>Conclusions: </strong>The diagnosis of AKI in dogs currently relies upon markers of glomerular function that are delayed and not specific to the tubular structural injury present during anaesthesia-related AKI. Several urinary biomarkers of renal tubular dysfunction, notably neutrophil gelatinase-associated lipocalin, clusterin, cystatin B, cystatin C and γ-glutamyl transferase, show promise as very early markers of perioperative AKI in dogs. However, for their reliable and routine use, a larger evidence base is required in the setting of canine perioperative AKI and there is a need for standardisation of measurement and reporting methodology.</p>\",\"PeriodicalId\":23626,\"journal\":{\"name\":\"Veterinary anaesthesia and analgesia\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary anaesthesia and analgesia\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1016/j.vaa.2025.08.036\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary anaesthesia and analgesia","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1016/j.vaa.2025.08.036","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Urinary biomarkers for early diagnosis of perioperative acute kidney injury in dogs: a narrative review.
Objective: To provide the knowledge and context necessary for veterinary anaesthetists to appraise and design studies utilising biomarkers as outcome measures for acute kidney injury (AKI).
Databases used: PubMed, Medline and CAB abstracts.
Conclusions: The diagnosis of AKI in dogs currently relies upon markers of glomerular function that are delayed and not specific to the tubular structural injury present during anaesthesia-related AKI. Several urinary biomarkers of renal tubular dysfunction, notably neutrophil gelatinase-associated lipocalin, clusterin, cystatin B, cystatin C and γ-glutamyl transferase, show promise as very early markers of perioperative AKI in dogs. However, for their reliable and routine use, a larger evidence base is required in the setting of canine perioperative AKI and there is a need for standardisation of measurement and reporting methodology.
期刊介绍：
Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome:
the basic sciences;
pathophysiology of disease as it relates to anaesthetic management
equipment
intensive care
chemical restraint of animals including laboratory animals, wildlife and exotic animals
welfare issues associated with pain and distress
education in veterinary anaesthesia and analgesia.
Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.
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