阿尔茨海默病中以杏仁核为主的路易小体与认知能力下降和杏仁核萎缩有关。

IF 4.6 2区医学 Q1 CLINICAL NEUROLOGY

Journal of Neurology Pub Date : 2025-09-12 DOI:10.1007/s00415-025-13360-1

Francisco C Almeida, Alexandra Santos, Tiago Jesus, Kathryn Gauthreaux, Charles N Mock, Walter A Kukull, John F Crary, Tiago Gil Oliveira

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引用次数: 0

摘要

简介：杏仁核主导型路易体（LB）病理常与晚期阿尔茨海默病（AD）相关。其临床意义尚未完全明确。我们研究了在AD神经病理改变（ADNC）的背景下，以杏仁核为主的LB对认知特征和脑萎缩的影响。方法：我们进行了一项来自国家阿尔茨海默病协调中心数据集的回顾性队列研究，评估纵向神经心理学和认知测试中杏仁核为主的LB和尾-吻侧LB分期的影响，以及横断面MRI对区域脑容量的影响。结果：与无LB和边缘LB的患者相比，杏仁核为主的LB与神经心理测试的特异性缺陷相关（p≤0.05）。与没有LB共病理的患者相比，这伴有右侧杏仁核局灶性萎缩（p≈0.02），尽管这一结果没有在错误发现率校正后存活下来。讨论：这些结果表明，杏仁核为主的LB是ADNC的一种重要的共病理形式，与认知能力下降和局灶性脑萎缩有关。

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Amygdala-predominant Lewy bodies associate with cognitive decline and amygdala atrophy in Alzheimer's disease neuropathological change.

Introduction: Amygdala-predominant Lewy body (LB) pathology occurs frequently in association with advanced Alzheimer's disease (AD). Its clinical significance is not yet fully clarified. We investigated the influence of amygdala-predominant LB in cognitive profiles and brain atrophy in the context of AD neuropathological change (ADNC).

Methods: We performed a retrospective cohort study from the National Alzheimer's Coordinating Center dataset assessing the influence of amygdala-predominant LB and caudo-rostral LB stages in longitudinal neuropsychological and cognitive testing, as well as on regional brain volume in cross-sectional MRI.

Results: Amygdala-predominant LB associated with specific deficits in neuropsychological testing compared with those without LB and with limbic LB (p ≤ 0.05). This was accompanied by focal atrophy of the right amygdala compared with those without LB co-pathology (p ≈ 0.02), although this result did not survive false discovery rate correction.

Discussion: These results suggest that amygdala-predominant LB is an important form of co-pathology in ADNC, associating with cognitive decline and focal brain atrophy.

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来源期刊

Journal of Neurology 医学-临床神经学

CiteScore

10.00

自引率

5.00%

发文量

558

审稿时长

1 months

期刊介绍： The Journal of Neurology is an international peer-reviewed journal which provides a source for publishing original communications and reviews on clinical neurology covering the whole field. In addition, Letters to the Editors serve as a forum for clinical cases and the exchange of ideas which highlight important new findings. A section on Neurological progress serves to summarise the major findings in certain fields of neurology. Commentaries on new developments in clinical neuroscience, which may be commissioned or submitted, are published as editorials. Every neurologist interested in the current diagnosis and treatment of neurological disorders needs access to the information contained in this valuable journal.