大角猫头鹰肌内和鼻内咪达唑仑的比较。

IF 0.5 4区 农林科学 Q3 VETERINARY SCIENCES
Michelle G Hawkins, Stephanie Chen, Camille Rushanaedy, Rachel M Hirota, Hugues Beaufrère
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引用次数: 0

摘要

目前很少有研究评价野生鸟类镇静剂的安全性和有效性。大多数镇静剂是可注射的药物,通常是肌肉注射(IM)或皮下注射(SC);然而,针头偶尔会因鸟在注射过程中挣扎而受伤。先前对鹦鹉和其他鸟类的研究探讨了鼻内(in)咪达唑仑与IM给药的效果;然而,这种传递方式还没有在猛禽等野生鸟类中得到很好的研究。据我们所知,只有一项研究发表了对猛禽咪达唑仑IN的评估。在本研究中,我们比较了咪达唑仑在大角猫头鹰(Bubo virginianus; GHOW)中的镇静作用。采用交叉研究设计,随机分配6名孕妇接受2 mg/kg IN或IM剂量的咪达唑仑。对于每种治疗方式,记录镇静评分、心率、呼吸频率和肌肉张力。采用线性混合模型对数据进行解释和比较。IN和IM治疗的结果显示,随着时间的推移,镇静的发作、翅膀、腿和下巴的整体肌肉张力、心率或呼吸频率没有显著差异。这些数据表明,与IM相同剂量的IN咪达唑仑镇静是一种可行的镇静选择。需要对其他种类的迅猛龙进行进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Intramuscular and Intranasal Midazolam in Great Horned Owls (Bubo virginianus).

There are few studies evaluating safe and effective sedatives for wild birds. Most sedatives are injectable drugs that are commonly administered intramuscularly (IM) or subcutaneously (SC); however, needle injuries occasionally occur from the bird struggling during the injection. Previous research in parrots and other bird species explored the effects of intranasal (IN) midazolam compared with IM administration; however, this delivery method has not been well studied in wild birds, such as raptors. To our knowledge, there is only 1 study that has been published evaluating midazolam IN in a raptor. In the present study, we compared midazolam sedation via IM and IN administration in great horned owls (Bubo virginianus; GHOW). Six GHOWs were randomly assigned to receive midazolam at 2 mg/kg IN or IM using a crossover study design. For each treatment type, sedation score, heart rate, respiratory rate, and muscle tone were recorded. Linear mixed models were used to interpret and compare the data. Results for both IN and IM treatments showed no significant difference in onset of sedation, overall muscle tone in the wings, legs, and jaw, heart rate, or respiratory rate over time. These data indicate that IN midazolam sedation at the same dose used IM is a viable option for sedation of GHOWs. Further research is needed for other species of raptors.

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来源期刊
Journal of Avian Medicine and Surgery
Journal of Avian Medicine and Surgery 农林科学-兽医学
CiteScore
0.90
自引率
0.00%
发文量
52
审稿时长
>36 weeks
期刊介绍: The Journal of Avian Medicine and Surgery is an international journal of the medicine and surgery of both captive and wild birds. Published materials include scientific articles, case reports, editorials, abstracts, new research, and book reviews.
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