通过医疗热线使用估计轻度至中度水痘相关感染的负担:丹麦儿童2015年至2023年的时间序列分析

IF 5.3 3区 医学 Q1 INFECTIOUS DISEASES
Amanda Marie Egeskov-Cavling, Caroline Klint Johannesen, Omid Rezahosseini, Mads Frederik Eiberg, Anja Poulsen, Fredrik Folke, Thea K Fischer
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引用次数: 0

摘要

在缺乏全国性水痘疫苗计划的情况下,假设丹麦每年获得水痘感染(水痘)的儿童比例与出生队列大小相对应,大约每年60,000人。水痘感染给家庭带来负担,增加了医疗保健的利用。以前的研究估计了需要住院治疗的严重水痘病例的疾病负担。然而,关于轻中度水痘病例负担的信息很少。我们的目标是在社区层面提供对轻度至中度水痘病例负担的见解。方法:我们利用来自非紧急医疗求助热线(1813求助热线)和国家住院登记的数据,对社区儿童中中度水痘病例的负担提供调整后的估计(结果:我们估计1813求助热线的20,439 (95% CI 17,378-23,501)个电话归因于水痘感染(vzv相关电话),与电话记录中记录的10,068个电话相比,这一比例增加了103.1%。vzv相关的年平均呼叫数为2271次。在纠正COVID-19大流行期间的不规则感染模式时,与vzv相关的年平均估计电话数为2561。在2023年前6个月,我们估计有2552个电话(95% CI 2170-2934)。vzv相关呼叫的总发病率为每10万人年623例(95% CI 529.49-716.06),年发病率从2021年的291例到2017年的910例不等。结论:1813个水痘求助电话是之前电话记录中报告的两倍,表明轻度至中度病例对医疗服务的影响比最初想象的要大。这突出了应对水痘感染负担估算挑战的重要性,并大大增加了社区一级轻度至中度水痘病例的负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Estimating the Burden of Mild-to-Moderate Varicella-Related Infections by Medical Helpline Usage: A Time Series Analysis from 2015 to 2023 Among Children in Denmark.

Introduction: In the absence of a national varicella vaccine program, it is assumed that the annual proportion of children in Denmark acquiring a varicella infection (chickenpox) corresponds to the birth cohort size, approximately 60,000 per year. Varicella infections impose a burden on families and increase healthcare utilization. Previous studies have estimated the disease burden of severe varicella cases requiring hospitalization. However, information about the burden of mild-to-moderate varicella cases is scarce. We aim to provide insights into the burden of mild-to-moderate varicella cases at the community level.

Method: We utilized data from the non-emergency medical helpline (1813 helpline) and national hospital admission register to provide adjusted estimates of the burden of moderate varicella cases at the community level among children (< 18 years) in Denmark from 2015 to 2023, applying time series regression analysis to counteract underreporting in the 1813 helpline.

Results: We estimated that 20,439 (95% CI 17,378-23,501) calls to the 1813 helpline were attributed to varicella infections (VZV-associated calls), a 103.1% additional proportion to the 10,068 calls documented in the call notes. The average yearly number of VZV-associated calls was 2271 calls. When correcting for irregular patterns of infection during the COVID-19 pandemic, the average yearly estimated number of VZV-associated calls was 2561. In the first 6 months of 2023, we estimated 2552 calls (95% CI 2170-2934). The overall incidence of VZV-associated calls is 623 per 100,000 person-years (95% CI 529.49-716.06), with annual incidence ranging from 291 in 2021 to 910 in 2017.

Conclusion: The 1813 helpline calls attributed to varicella were double the numbers reported previously in the call notes, indicating a larger impact of mild-to-moderate cases on healthcare services than initially thought. This highlights the importance of addressing challenges with varicella infection burden estimates and adds considerably to the burden of mild-to-moderate cases of varicella on a community level.

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来源期刊
Infectious Diseases and Therapy
Infectious Diseases and Therapy Medicine-Microbiology (medical)
CiteScore
8.60
自引率
1.90%
发文量
136
审稿时长
6 weeks
期刊介绍: Infectious Diseases and Therapy is an international, open access, peer-reviewed, rapid publication journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of infectious disease therapies and interventions, including vaccines and devices. Studies relating to diagnostic products and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. Areas of focus include, but are not limited to, bacterial and fungal infections, viral infections (including HIV/AIDS and hepatitis), parasitological diseases, tuberculosis and other mycobacterial diseases, vaccinations and other interventions, and drug-resistance, chronic infections, epidemiology and tropical, emergent, pediatric, dermal and sexually-transmitted diseases.
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