砷通过饮用水暴露对色素紊乱的影响：荟萃分析和贝叶斯基准浓度分析

IF 3.6 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Trace Elements in Medicine and Biology Pub Date : 2025-09-09 DOI:10.1016/j.jtemb.2025.127744

Rujin Wang , Xingrun Li , Yuanjie Wei , Tingxu Jin , Yuanhui Zhu , Ting Zhang , Rui Yan , Heran Li , Koichi Kato , Runa A , Qianlei Yang , Yan An

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引用次数: 0

摘要

皮肤病变是水源性砷中毒的早期明显症状，而色素紊乱是皮肤病变的首要症状。因此，深入分析色素紊乱与饮用水中砷浓度的关系，可作为制定饮用水砷标准的依据。然而，目前尚不清楚砷是否主要引起色素沉着或色素沉着，以及就皮肤症状而言，什么剂量的砷是安全的。方法采用Stata 17.0软件进行meta分析。检索截止到2024年12月1日的PubMed、Embase、Web of Science、CNKI、VIP中文期刊服务平台、万方数据库。采用贝叶斯基准剂量（BBMD）分析系统估计基准剂量（BMD）及其置信下限（BMDL）。结果共纳入12篇文章，共36670条观察结果。荟萃分析结果表明，通过饮用水接触砷与色素紊乱有关，色素沉着是最常见的表现。BBMD结果表明弹道导弹防御系统的饮用水中砷浓度和色素紊乱之间的联系被确定为4.93 μg / L (BMDL1 = 4.85 μg / L), 6.54 μg / L (BMDL5 = 6.19 μg / L), 8.41 μg / L (BMDL10 = 7.80 μg / L)当使用1 %的基础代谢率,5 %,10 %。结论色素沉着是饮水砷暴露最常见的表现，可能与角化病和皮肤癌有关。饮用水中砷含量超过7.80 μg /L会增加10 %的色素紊乱风险，这也会导致更严重的角化病和皮肤癌。在此基础上，提出了三个中期目标，为建立更严格的饮用水砷限量提供了依据。

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Impacts of arsenic exposure through drinking water on pigment disorders: A meta-analysis and a Bayesian benchmark concentration analysis

Background

Skin lesions are an early and distinct symptom of waterborne arsenic poisoning, while pigment disorder is the first symptom of skin lesions. Therefore, an in-depth analysis of the association between pigment disorders and arsenic concentration in drinking water can be used as a basis for the development of arsenic drinking water standards. However, it remains unclear whether arsenic primarily causes depigmentation or hyperpigmentation, and what dose of arsenic is safe with respect to skin symptoms.

Methods

A meta-analysis was performed using Stata 17.0 software. PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), VIP Chinese Journal Service Platform, and Wanfang Data databases were searched up to December 1, 2024. The Bayesian benchmark dose (BBMD) analysis system was used to estimate the benchmark dose (BMD) and its lower confidence limit (BMDL).

Results

Twelve articles with 36, 670 observations were included. The meta-analysis results indicated that arsenic exposure through drinking water was associated with pigment disorders, with hyperpigmentation being the most common manifestation. The BBMD results suggested that BMDs for the association between arsenic concentrations in drinking water and pigment disorders were determined to be 4.93 μg/L (BMDL1 = 4.85 μg/L), 6.54 μg/L (BMDL5 = 6.19 μg/L), 8.41 μg/L (BMDL10 = 7.80 μg/L) when using BMRs of 1 %, 5 %, and 10 %.

Conclusions

Hyperpigmentation is the most common manifestation caused by drinking water arsenic exposure and may link to keratoses and skin cancer. Arsenic in drinking water over 7.80 μg /L raises 10 % risk of pigment disorders, which can also lead to more severe keratosis and skin cancer. Based on these findings, three interim targets are proposed, providing a basis for the establishment of stricter arsenic limits in drinking water.

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来源期刊

Journal of Trace Elements in Medicine and Biology 医学-内分泌学与代谢

CiteScore

6.60

自引率

2.90%

发文量

202

审稿时长

85 days

期刊介绍： The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods. Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.