{"title":"单侧乳头周围脉络膜内空化的深视神经头结构与视盘形态比较","authors":"Kaho Akiyama MD , Shuichiro Aoki MD , Shiroaki Shirato MD, PhD , Rei Sakata MD, PhD , Megumi Honjo MD, PhD , Makoto Aihara MD, PhD , Hitomi Saito MD, PhD","doi":"10.1016/j.xops.2025.100908","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><div>To compare background characteristics, deep optic nerve head (ONH) structures, and optic disc morphology in participants with unilateral peripapillary intrachoroidal cavitation (PICC).</div></div><div><h3>Design</h3><div>Retrospective cross-sectional study.</div></div><div><h3>Participants</h3><div>One hundred six eyes of 53 participants with unilateral PICC determined on OCT.</div></div><div><h3>Methods</h3><div>Twelve ONH-centered OCT radial slices were used to manually measure Bruch membrane opening (BMO) area, BMO ovality, scleral flange opening (SFO) area, SFO ovality, and SFO/BMO offset magnitude which represents the degree of SFO/BMO centroid displacement and clinically corresponds to the peripapillary atrophy–gamma and delta zones. Optic disc tilt, rotation, area, and longest and shortest diameters were measured from line scanning laser ophthalmoscopy images.</div></div><div><h3>Main Outcome Measures</h3><div>Paired <em>t</em> tests and Wilcoxon signed-rank tests were used to compare background characteristics and obtained parameters between PICC eyes and their contralateral eyes. False discovery rate was controlled using the Benjamini–Hochberg method to account for multiple comparisons.</div></div><div><h3>Results</h3><div>Peripapillary intrachoroidal cavitation eyes showed significantly larger BMO area (<em>P</em> < 0.001) and its ovality (<em>P</em> = 0.020), larger SFO area (<em>P</em> = 0.003), larger SFO/BMO offset magnitude (<em>P</em> = 0.007), greater optic disc tilt (<em>P</em> < 0.001), and smaller optic disc shortest diameter (<em>P</em> = 0.010). There was no significant difference in axial length (AL) (<em>P</em> = 0.081) and optic disc rotation (<em>P</em> = 0.067).</div></div><div><h3>Conclusions</h3><div>Although AL was similar between PICC eyes and their contralateral eyes, significant intereye differences in deep ONH structures and optic disc morphology were observed. Peripapillary intrachoroidal cavitation eyes exhibited a more elliptically expanded BMO, larger SFO, greater SFO/BMO misalignment, and greater optic disc tilt, which are structural changes associated with border tissue elongation. Our findings indicate a strong association between the presence of PICC and myopia-related characteristic deep ONH remodeling, providing a foundation for understanding structural abnormalities in myopic eyes.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>","PeriodicalId":74363,"journal":{"name":"Ophthalmology science","volume":"6 1","pages":"Article 100908"},"PeriodicalIF":4.6000,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of Deep Optic Nerve Head Structures and Optic Disc Morphology in Unilateral Peripapillary Intrachoroidal Cavitation\",\"authors\":\"Kaho Akiyama MD , Shuichiro Aoki MD , Shiroaki Shirato MD, PhD , Rei Sakata MD, PhD , Megumi Honjo MD, PhD , Makoto Aihara MD, PhD , Hitomi Saito MD, PhD\",\"doi\":\"10.1016/j.xops.2025.100908\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><div>To compare background characteristics, deep optic nerve head (ONH) structures, and optic disc morphology in participants with unilateral peripapillary intrachoroidal cavitation (PICC).</div></div><div><h3>Design</h3><div>Retrospective cross-sectional study.</div></div><div><h3>Participants</h3><div>One hundred six eyes of 53 participants with unilateral PICC determined on OCT.</div></div><div><h3>Methods</h3><div>Twelve ONH-centered OCT radial slices were used to manually measure Bruch membrane opening (BMO) area, BMO ovality, scleral flange opening (SFO) area, SFO ovality, and SFO/BMO offset magnitude which represents the degree of SFO/BMO centroid displacement and clinically corresponds to the peripapillary atrophy–gamma and delta zones. Optic disc tilt, rotation, area, and longest and shortest diameters were measured from line scanning laser ophthalmoscopy images.</div></div><div><h3>Main Outcome Measures</h3><div>Paired <em>t</em> tests and Wilcoxon signed-rank tests were used to compare background characteristics and obtained parameters between PICC eyes and their contralateral eyes. False discovery rate was controlled using the Benjamini–Hochberg method to account for multiple comparisons.</div></div><div><h3>Results</h3><div>Peripapillary intrachoroidal cavitation eyes showed significantly larger BMO area (<em>P</em> < 0.001) and its ovality (<em>P</em> = 0.020), larger SFO area (<em>P</em> = 0.003), larger SFO/BMO offset magnitude (<em>P</em> = 0.007), greater optic disc tilt (<em>P</em> < 0.001), and smaller optic disc shortest diameter (<em>P</em> = 0.010). There was no significant difference in axial length (AL) (<em>P</em> = 0.081) and optic disc rotation (<em>P</em> = 0.067).</div></div><div><h3>Conclusions</h3><div>Although AL was similar between PICC eyes and their contralateral eyes, significant intereye differences in deep ONH structures and optic disc morphology were observed. Peripapillary intrachoroidal cavitation eyes exhibited a more elliptically expanded BMO, larger SFO, greater SFO/BMO misalignment, and greater optic disc tilt, which are structural changes associated with border tissue elongation. Our findings indicate a strong association between the presence of PICC and myopia-related characteristic deep ONH remodeling, providing a foundation for understanding structural abnormalities in myopic eyes.</div></div><div><h3>Financial Disclosure(s)</h3><div>Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.</div></div>\",\"PeriodicalId\":74363,\"journal\":{\"name\":\"Ophthalmology science\",\"volume\":\"6 1\",\"pages\":\"Article 100908\"},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2025-08-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Ophthalmology science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666914525002064\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmology science","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666914525002064","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Comparison of Deep Optic Nerve Head Structures and Optic Disc Morphology in Unilateral Peripapillary Intrachoroidal Cavitation
Purpose
To compare background characteristics, deep optic nerve head (ONH) structures, and optic disc morphology in participants with unilateral peripapillary intrachoroidal cavitation (PICC).
Design
Retrospective cross-sectional study.
Participants
One hundred six eyes of 53 participants with unilateral PICC determined on OCT.
Methods
Twelve ONH-centered OCT radial slices were used to manually measure Bruch membrane opening (BMO) area, BMO ovality, scleral flange opening (SFO) area, SFO ovality, and SFO/BMO offset magnitude which represents the degree of SFO/BMO centroid displacement and clinically corresponds to the peripapillary atrophy–gamma and delta zones. Optic disc tilt, rotation, area, and longest and shortest diameters were measured from line scanning laser ophthalmoscopy images.
Main Outcome Measures
Paired t tests and Wilcoxon signed-rank tests were used to compare background characteristics and obtained parameters between PICC eyes and their contralateral eyes. False discovery rate was controlled using the Benjamini–Hochberg method to account for multiple comparisons.
Results
Peripapillary intrachoroidal cavitation eyes showed significantly larger BMO area (P < 0.001) and its ovality (P = 0.020), larger SFO area (P = 0.003), larger SFO/BMO offset magnitude (P = 0.007), greater optic disc tilt (P < 0.001), and smaller optic disc shortest diameter (P = 0.010). There was no significant difference in axial length (AL) (P = 0.081) and optic disc rotation (P = 0.067).
Conclusions
Although AL was similar between PICC eyes and their contralateral eyes, significant intereye differences in deep ONH structures and optic disc morphology were observed. Peripapillary intrachoroidal cavitation eyes exhibited a more elliptically expanded BMO, larger SFO, greater SFO/BMO misalignment, and greater optic disc tilt, which are structural changes associated with border tissue elongation. Our findings indicate a strong association between the presence of PICC and myopia-related characteristic deep ONH remodeling, providing a foundation for understanding structural abnormalities in myopic eyes.
Financial Disclosure(s)
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
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