考虑量子约束的高性能JLCSG MOSFET生物传感器用于多区域中性生物分子物种检测

IF 3 Q2 PHYSICS, CONDENSED MATTER
Qing-an Ding, Shengyuan Fan, Fangfang Ning, Jianyu Li, Bing Chen, Yandong Peng, Fei Wang, Dasheng Diao, Yuhua Gao
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引用次数: 0

摘要

本研究展示了一种基于短通道无结圆柱形环栅MOSFET的高性能介质调制生物传感器,该传感器具有出色的栅极控制能力,可有效抑制短通道效应(SCEs)。特别是,一种新型的分析模型结合了耗尽电荷和自由电荷,通过确保在不同的操作区域的高灵敏度和稳定性,显著提高了检测精度。在每个区域内,通过求解Schrödinger方程对量子约束效应(QCEs)进行了严格的评估,揭示了小半径通道中量子化的特征能和相应的电子密度分布。此外,利用最低特征能的位移来定义一个灵敏度度量,该度量直接探测生物分子结合的量子级扰动,有效地放大了传感信号并提高了预测精度。随后,分析确定了非理想的不完全生物分子杂交和界面陷阱电荷(ITCs)是性能下降的主要来源,为有针对性的缓解提供了明确的途径。通过在关键性能指标和时序响应约束的指导下优化结构参数,所提出的器件具有0.383的优越阈值电压灵敏度和1 × 1013的异常高电流开关比。因此,本研究非常适合于中性生物分子检测,甚至为生物传感器的设计和多功能应用提供了强有力的指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
High-performance JLCSG MOSFET biosensor considering quantum confinement for multi-region neutral biomolecule species detection
This work demonstrates a high-performance dielectrically modulated biosensor based on short-channel junctionless cylindrical surrounding-gate MOSFET with excellent gate control capability to efficiently suppress the short channel effects (SCEs). Particularly, a novel analytical model incorporating both depleted and free charges has been developed, which significantly enhances detection precision by ensuring high sensitivity and stability across diverse operating regions. Within each region, the quantum confinement effects (QCEs) are rigorously evaluated by solving the Schrödinger equation, revealing the quantized eigenenergies and the corresponding electron density distribution in small-radius channels. Furthermore, the shift in the lowest eigenenergy is leveraged to define a sensitivity metric that directly probes the quantum-level perturbations from biomolecule binding, which effectively amplifies the sensing signal and improves predictive accuracy. Afterwards, the analysis identifies non-ideal incomplete biomolecule hybridization and interface trap charges (ITCs) as the primary sources of performance degradation, providing a clear path for their targeted mitigation. By optimizing the structural parameters guided by key performance metrics and timing response constraints, the proposed device exhibits a superior threshold voltage sensitivity of 0.383 and an exceptionally high current switching ratio of 1 × 1013. Therefore, this study is highly suitable for neutral biomolecule detection, even offering robust guidance for the design and multifunctional application of biosensors.
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CiteScore
6.50
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