血清骨桥蛋白水平预测乙型肝炎相关急性慢性肝衰竭患者的短期预后

IF 2 4区医学 Q2 IMMUNOLOGY

Journal of Virus Eradication Pub Date : 2025-09-08 DOI:10.1016/j.jve.2025.100606

Yu Liu , Miao Fang , Hongying Guo , Xin Zhang , Xue Mei , Longshan Ji , Wei Yuan , Yating Gao , Jiefei Wang , Zhiping Qian , Man Li , Yueqiu Gao

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引用次数: 0

摘要

多项分析表明，骨桥蛋白（OPN）参与急性和慢性肝脏疾病。我们的目的是研究血清OPN在预测乙型肝炎相关急性-慢性肝衰竭（HBV-ACLF）患者短期预后中的价值。方法对205例HBV-ACLF患者进行回顾性研究，并根据患者90天预后将其分为幸存者和非幸存者。采用多因素Cox回归和受试者工作特征曲线评价血清OPN水平对HBV-ACLF患者90天预后的预测价值。观察不同OPN水平（<36.8 ng/ml;≥36.8 ng/ml）的患病率及其与90天预后的关系。结果HBV-ACLF患者血清OPN水平明显高于HBV-LC患者、CHB患者和健康人。根据OPN的临界值（36.8 ng/ml）将患者分为低、高水平OPN组。根据Kaplan-Meier分析，生存曲线显示，高OPN水平的患者比低OPN水平的患者生存期明显较差。重要的是，多因素Cox回归分析显示，根据完全调整的模型iv，血浆OPN水平是HBV-ACLF患者90天不良结局的独立危险因素。结论血浆OPN水平是预测HBV-ACLF患者短期预后的有临床意义的生物标志物。

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Serum osteopontin levels predict short-term outcomes in patients with hepatitis B-related acute-on-chronic liver failure

Background

Multiple analyses have suggested that osteopontin (OPN) is involved in acute and chronic liver disease. We aimed to investigate the value of serum OPN in predicting the short-term prognosis of patients with hepatitis B-related acute-on-chronic liver failure (HBV-ACLF).

Methods

A total of 205 patients with HBV-ACLF were enrolled in a retrospective study and stratified into survivors and non-survivors according to their 90-day prognosis. Multivariate Cox regression and receiver operating characteristic curves were used to evaluate the predictive value of serum OPN levels for the 90-day prognosis of patients with HBV-ACLF.The prevalence of different OPN levels (<36.8 ng/ml; ≥36.8 ng/ml) and their relationship with 90-day prognosis were investigated.

Results

Patients with HBV-ACLF had significantly higher serum OPN levels than patients with HBV-LC, patients with CHB, and healthy subjects. Patients were assigned to low- and high-level OPN groups according to the cut-off value of OPN (36.8 ng/ml). Survival curves revealed that patients with high OPN levels had significantly poorer survival than those with low OPN levels, as determined using Kaplan-Meier analysis. Importantly, Multivariate Cox regression analysis revealed that OPN levels were an independent risk factor for 90-day adverse outcomes in patients with HBV-ACLF according to the fully adjusted Model IV.

Conclusions

Our results demonstrated that plasma OPN level is a clinically meaningful biomarker for predicting the short-term prognosis of patients with HBV-ACLF.

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来源期刊

Journal of Virus Eradication Medicine-Public Health, Environmental and Occupational Health

CiteScore

6.10

自引率

1.80%

发文量

审稿时长

39 weeks

期刊介绍： The Journal of Virus Eradication aims to provide a specialist, open-access forum to publish work in the rapidly developing field of virus eradication. The Journal covers all human viruses, in the context of new therapeutic strategies, as well as societal eradication of viral infections with preventive interventions. The Journal is aimed at the international community involved in the prevention and management of viral infections. It provides an academic forum for the publication of original research into viral reservoirs, viral persistence and virus eradication and ultimately development of cures. The Journal not only publishes original research, but provides an opportunity for opinions, reviews, case studies and comments on the published literature. It focusses on evidence-based medicine as the major thrust in the successful management of viral infections.The Journal encompasses virological, immunological, epidemiological, modelling, pharmacological, pre-clinical and in vitro, as well as clinical, data including but not limited to drugs, immunotherapy and gene therapy. It is an important source of information on the development of vaccine programs and preventative measures aimed at virus eradication.