喀麦隆杜阿拉充血性心力衰竭患者高血压和血脂异常的临床流行病学分析

Q2 Medicine

Obesity Medicine Pub Date : 2025-09-01 DOI:10.1016/j.obmed.2025.100638

Djeukeu Asongni William , Julien Armel Agamou Assiene , Loick Pradel Kojom Foko , Pierre Mintom , Moni Michelle , William Dakam , Christine Fernande Nyangono Biyegue

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引用次数: 0

摘要

背景：心血管和动脉粥样硬化性血管疾病是世界范围内重要的死亡原因。本研究旨在确定喀麦隆充血性心力衰竭患者高血压（HTA）和血脂异常的患病率、模式和决定因素。方法2017年3月至2018年8月，在Deido地区医院进行了一项横断面研究，涉及98名诊断为心力衰竭的患者。记录了社会人口学、临床、人体测量学和生理特征的数据。血脂成分（即总胆固醇- TC，低密度脂蛋白胆固醇- LDL-c，高密度脂蛋白胆固醇- HDL-c，甘油三酯- TG）从空腹血液中测定。HTA的诊断采用临床标准程序。结果HTA和血脂异常的总患病率分别为45.9%和82.7%。血脂异常，主要表现为高胆固醇血症（66.3%）和高ldl胆固醇血症（68.4%）。HTA在血脂异常、高胆固醇血症和高甘油三酯血症患者中更为普遍。血液中TC水平的增加与HTA风险增加1.04倍相关（95% CI 1.02-1.06, p < 0.0001）。与男性相比，女性患血脂异常的风险降低了77% （aOR = 0.23, p = 0.007）。血糖一直被发现是高胆固醇血症（aOR = 1.87, p < 0.05）、低hdl胆固醇血症（aOR = 6.38, p < 0.05）和高ldl胆固醇血症（aOR = 10.22, p < 0.05）的危险因素。结论这些发现要求系统监测HTA状态和脂质谱，以减轻心脏代谢并发症。

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Clinico-epidemiology analysis of hypertension and dyslipidaemia among patients with congestive heart failure in Douala, Cameroon

Background

Cardiovascular and atherosclerotic vascular diseases are important cause of mortality worldwide. This study was designed to determine the prevalence, patterns, and determinants of hypertension (HTA) and dyslipidaemia in Cameroonian patients living with congestive heart failure.

Methods

Between March 2017 and August 2018, a cross-sectional study was conducted at the Deido District Hospital involving 98 patients diagnosed with heart failure. Data on socio-demographic, clinical, anthropometric, and physiological features were documented. Lipid profile components (i.e., total cholesterol – TC, low density lipoprotein cholesterol – LDL-c, high density lipoprotein cholesterol – HDL-c, and triglycerides – TG) were determined from overnight fasting blood. HTA was diagnosed using clinical standard procedures.

Results

The overall prevalence of HTA and dyslipidaemia was 45.9 % and 82.7 %. Disorders in lipid profile were found, which were mainly represented by hypercholesteremia (66.3 %) and hyper-LDL cholesterolemia (68.4 %). HTA was more prevalent in patients with dyslipidaemia, hypercholesterolemia, and hypertriglyceridemia. A one-unity increase in blood level of TC was associated with an increase in HTA risk by 1.04 times (95 %CI 1.02–1.06, p < 0.0001). The risk of dyslipidaemia was reduced in females by 77 % (aOR = 0.23, p = 0.007) compared to males. Glycaemia was consistently found to be a risk factor for hypercholesteremia (aOR = 1.87, p < 0.05), hypo-HDL cholesterolemia (aOR = 6.38, p < 0.05), and hyper-LDL cholesterolemia (aOR = 10.22, p < 0.05).

Conclusions

These findings call for systematic monitoring of HTA status and lipid profiles in this population to alleviate cardio-metabolic complications.

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.