糖尿病神经病变的最新进展：蛋白质作为治疗靶点

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-09-01 DOI:10.1016/j.isci.2025.113466

Gurjeet Kaur , Salaha Osman Ali , Alberto Santos , Tina Okdahl , Anne-Marie Wegeberg , Tarunveer S. Ahluwalia , Christian Stevns Hansen , David Wishart , Nicolai J. Wewer Albrechtsen , Birgitte Brock , Troels Staehelin Jensen , Peter Rossing , Christina Brock , Cristina Legido-Quigley , Karolina Sulek

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引用次数: 0

摘要

糖尿病性神经病变是一种使人衰弱的糖尿病并发症，其特征是神经损伤，可导致麻木、足部溃疡和截肢，是糖尿病患者发病和死亡的主要原因。除了疼痛管理之外，目前还没有治疗糖尿病神经病变的方法。蛋白质研究的最新进展已经确定了与疾病发展和进展相关的潜在靶点。本文综述了糖尿病神经病变中蛋白质可能作为药物靶点的最新研究及其在多元醇代谢、氧化应激和细胞因子调节等相关过程中的作用。此外，我们还从单细胞和空间分辨率的角度全面介绍了当前的发展和发现，揭示了背根神经节、坐骨神经、三叉神经节或雪旺细胞中不受调节的蛋白质谱。最后，我们讨论了蛋白质组学技术识别蛋白质和相关信号通路的好处，以更好地了解糖尿病神经病变的来源。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Current advances in diabetic neuropathy: Proteins as therapeutic targets

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Current advances in diabetic neuropathy: Proteins as therapeutic targets

Diabetic neuropathy is a debilitating complication of diabetes characterized by nerve damage that may lead to numbness, foot ulcers, and amputations, and is a major cause of morbidity and mortality in people with diabetes. There are no treatments available for diabetic neuropathy aside from pain management. Recent advances in protein research have identified potential targets associated with the disease development and progression. This review explores the latest studies identifying proteins as possible drug targets in diabetic neuropathy and their role in relevant processes such as polyol metabolism, oxidative stress, and cytokine regulation. Additionally, we provide a comprehensive view of current developments and discoveries at single cell and spatial resolution that have revealed deregulated protein profiles in the dorsal root ganglia, sciatic nerve, trigeminal ganglion, or Schwann cells. Finally, we discuss the benefits of proteomics technologies to identify proteins and associated signaling pathways to better understand the source of diabetic neuropathy.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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