咖啡摄入量与未来静脉血栓栓塞风险的重复测量——特朗德拉格健康研究和特罗姆瑟研究

IF 3.4 3区医学 Q2 HEMATOLOGY

Research and Practice in Thrombosis and Haemostasis Pub Date : 2025-08-01 DOI:10.1016/j.rpth.2025.103019

Melliane Muteba Olsen , Sigrid K. Brækkan , Kristian Hveem , Kjersti Grønning , John-Bjarne Hansen

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引用次数: 0

摘要

有限数量的流行病学研究报告了咖啡消费与静脉血栓栓塞（VTE）风险之间的关系的混合结果。目的：我们的目的是在一个以人群为基础的队列中，研究长期反复测量咖啡摄入量与静脉血栓栓塞风险之间的关系。方法从特罗姆瑟研究的4项调查（入组时间：1994-2008）和特朗德拉格健康研究的2项调查（入组时间：1995-2008）中招募参与者（N = 112,784），随访至2020年。每次调查都会更新咖啡消费量和主要混杂因素（年龄、性别、体重指数、身体活动、动脉心血管疾病和癌症）的信息。时变Cox回归模型用于计算不同咖啡消费类别的静脉血栓栓塞风险比（hr）。结果随访共178696个观察期，静脉血栓栓塞3419例。观察到阈值效应，每天喝1到2杯咖啡的人患静脉血栓栓塞的风险比不喝咖啡的人低21% （HR, 0.79; 95% CI, 0.68-0.93）。喝咖啡（1-2杯/天）与静脉血栓形成的负相关在肺栓塞（相对危险度，0.72；95%可信区间，0.58-0.89）比深静脉血栓形成（相对危险度，0.87；95%可信区间，0.70-1.09）更为明显。在对主要潜在混杂因素进行调整后，静脉血栓栓塞的hr在咖啡消费量较高的类别中保持相似。在女性和男性中，喝咖啡与静脉血栓栓塞风险的关系是相似的。结论：咖啡摄入与静脉血栓栓塞的总体风险非线性降低有关，尤其是肺栓塞。

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Repeated measures of coffee consumption and risk of future incident venous thromboembolism—the Trøndelag Health Study and the Tromsø study

Background

A limited number of epidemiological studies have reported mixed results on the association between coffee consumption and risk of venous thromboembolism (VTE).

Objectives

We aimed to investigate the association between repeated measures of coffee consumption over time and risk of incident VTE in a large population-based cohort.

Methods

Participants (N = 112,784) were recruited from 4 surveys of the Tromsø Study (enrolment: 1994-2008) and 2 surveys of the Trøndelag Health Study (enrolment: 1995-2008) and followed through 2020. Information on coffee consumption and major confounders (age, sex, body mass index, physical activity, arterial cardiovascular diseases, and cancer) was updated at each survey. Time-varying Cox regression models were used to calculate hazard ratios (HRs) for VTE across categories of coffee consumption.

Results

There were 178,696 observation periods and 3419 VTEs during follow-up. A threshold effect was observed, and those who drank 1 to 2 cups of coffee per day had 21% lower risk of overall VTE (HR, 0.79; 95% CI, 0.68-0.93) than nonconsumers. The inverse association of coffee consumption (1-2 cups/d) with VTE was more pronounced for pulmonary embolism (HR, 0.72; 95% CI, 0.58-0.89) than for deep vein thrombosis (HR, 0.87; 95% CI, 0.70-1.09). The HRs for VTE remained similar across categories of higher coffee consumption after adjustments for major potential confounders. The association of coffee consumption with VTE risk was similar in women and men.