绝经后妇女子宫体胚胎性横纹肌肉瘤1例报告及文献复习

IF 1.3 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports Pub Date : 2025-09-04 DOI:10.1016/j.gore.2025.101937

Misako Omuro , Yuichi Imai , Yuki Ogawara , Taichi Mizushima , Erika Muraoka , Shoji Yamanaka , Satoshi Fujii , Etsuko Miyagi

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引用次数: 0

摘要

背景：habdomyosarcoma （RMS）是一种罕见的恶性间质肿瘤，主要影响儿童。发生在成人子宫体，特别是绝经后妇女，是非常罕见的。病例介绍一名60岁绝经后无妊娠妇女，表现为生殖器异常出血3个月。盆腔检查发现一个易碎的肿块从子宫体延伸出来。活检证实胚胎性RMS。她接受改良根治性子宫切除术和双侧输卵管卵巢切除术以完成手术切除。给予一个周期的辅助VAC化疗（长春新碱、放线菌素D和环磷酰胺），但在她的要求下停止。术后未见残留病变，术后12个月无病变。结论成人发病的子宫体胚胎性RMS较为罕见，缺乏规范的治疗方案。早期诊断，完全手术切除和个体化治疗是必不可少的。文献回顾强调临床特点，治疗策略和预后考虑。

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Embryonal rhabdomyosarcoma of the uterine corpus in a postmenopausal Woman: A case report and literature Review

Background

Rhabdomyosarcoma (RMS) is a rare malignant mesenchymal tumor, primarily affecting children. Occurrence in the uterine corpus of adults, particularly postmenopausal women, is extremely uncommon.

Case Presentation

A 60-year-old postmenopausal nulligravid woman presented with abnormal genital bleeding for three months. Pelvic examination revealed a friable mass extending from the uterine corpus. Biopsy confirmed embryonal RMS. She underwent modified radical hysterectomy with bilateral salpingo-oophorectomy for complete surgical resection. One cycle of adjuvant VAC chemotherapy (vincristine, actinomycin D, and cyclophosphamide) was administered but discontinued at her request. No residual disease was observed postoperatively, and she remains disease-free 12 months after surgery.

Conclusion

Adult-onset uterine corpus embryonal RMS is rare, and standardized treatment protocols are lacking. Early diagnosis, complete surgical resection, and individualized therapy are essential. A literature review highlights clinical characteristics, treatment strategies, and prognostic considerations.

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来源期刊

Gynecologic Oncology Reports OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

183

审稿时长

41 days

期刊介绍： Gynecologic Oncology Reports is an online-only, open access journal devoted to the rapid publication of narrative review articles, survey articles, case reports, case series, letters to the editor regarding previously published manuscripts and other short communications in the field of gynecologic oncology. The journal will consider papers that concern tumors of the female reproductive tract, with originality, quality, and clarity the chief criteria of acceptance.