解码肝细胞癌中环状rna编码蛋白的功能网络：从癌变到临床转化

IF 13 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of Advanced Research Pub Date : 2025-09-11 DOI:10.1016/j.jare.2025.09.017

Jundan Zheng, Tianle He, Jiaxin Chen, Jixin Zhao, Shuobo Zhang, Zhenguo Yang

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引用次数: 0

摘要

背景：肝细胞癌（HCC）是一种高度异质性的恶性肿瘤，治疗选择有限。环状rna （circRNAs）已成为HCC的关键调节因子。它们通过作为microRNA （miRNA）海绵、蛋白质相互作用介质和外泌体信使来影响致癌途径，并且它们的蛋白质编码潜力进一步增强了它们在癌症进展中的功能重要性。本文旨在探讨circrna编码蛋白在HCC转移、凋亡、治疗耐药和代谢重编程中的作用。并讨论了最新的检测方法和基于rna的治疗策略。环状rna编码的蛋白质可以调节关键的细胞过程，并作为有前途的生物标志物和治疗靶点。该综述整合了各种癌症类型的研究结果，并强调了目前在递送、检测灵敏度和机制阐明方面的挑战，解决这些问题对于将circrna衍生蛋白转化为HCC的精准药物至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Decoding the functional network of circular RNAs encoding proteins in hepatocellular carcinoma: from carcinogenesis to clinical transformation

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Decoding the functional network of circular RNAs encoding proteins in hepatocellular carcinoma: from carcinogenesis to clinical transformation

Background

Hepatocellular carcinoma (HCC) is a highly heterogeneous malignancy with limited therapeutic options. Circular RNAs (circRNAs) have emerged as key regulators in HCC. They influence oncogenic pathways by acting as microRNA (miRNA) sponges, protein interaction mediators, and exosomal messengers, and their protein-coding potential further boosts their functional importance in cancer progression.

Aim of review

This review aims to evaluate the roles of circRNA-encoded proteins in HCC metastasis, apoptosis, therapy resistance, and metabolic reprogramming. It also discusses the latest detection methods and RNA-based therapeutic strategies.

Key scientific concepts of review

circRNAs-encoded proteins can modulate key cellular processes and serve as promising biomarkers and therapeutic targets. The review integrates findings across cancer types and emphasizes current challenges in delivery, detection sensitivity, and mechanistic elucidation Tackling these issues will be essential for translating circRNA-derived proteins into precision medicine for HCC.

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来源期刊

Journal of Advanced Research Multidisciplinary-Multidisciplinary

CiteScore

21.60

自引率

0.90%

发文量

280

审稿时长

12 weeks

期刊介绍： Journal of Advanced Research (J. Adv. Res.) is an applied/natural sciences, peer-reviewed journal that focuses on interdisciplinary research. The journal aims to contribute to applied research and knowledge worldwide through the publication of original and high-quality research articles in the fields of Medicine, Pharmaceutical Sciences, Dentistry, Physical Therapy, Veterinary Medicine, and Basic and Biological Sciences. The following abstracting and indexing services cover the Journal of Advanced Research: PubMed/Medline, Essential Science Indicators, Web of Science, Scopus, PubMed Central, PubMed, Science Citation Index Expanded, Directory of Open Access Journals (DOAJ), and INSPEC.