铁催化吡啶基磷盐与CO2的羧化反应。

IF 3.6 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-09-12 DOI:10.1021/acs.joc.5c01797

Shibiao Tang, , , Bin Li, , and , Baiquan Wang*,

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引用次数: 0

摘要

铁是地球上含量最多的过渡金属，毒性最低。然而，利用二氧化碳的铁催化羧化反应仍未得到充分的研究。在这里，我们报道了一种高效的铁催化二氧化碳吡啶基磷盐的羧化反应，这使得合成各种高附加值的异烟肼衍生物成为可能。该反应对多种官能团具有良好的耐受性，具有很高的合成实用性。该反应的一级催化循环可能包括铁(0)-铁(I)-铁(II)-铁(0)氧化还原序列。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Iron-Catalyzed Carboxylation of Pyridylphosphonium Salts with CO2

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Iron-Catalyzed Carboxylation of Pyridylphosphonium Salts with CO2

Iron is the most abundant transition metal on earth and exhibits the lowest toxicity. However, the iron-catalyzed carboxylation reaction utilizing CO₂ remains significantly underexplored. Here we report an efficient iron-catalyzed carboxylation of pyridylphosphonium salts with CO₂, which enables the synthesis of a variety of high value-added isoniazid derivatives. This reaction demonstrates excellent tolerance for a wide range of functional groups and possesses high synthetic practicality. The primary catalytic cycle in this reaction may involve an Fe(0)–Fe(I)–Fe(II)–Fe(0) redox sequence.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.