Bhairavy J Puviindran, Shannon Wallace, Katayoun Ayasoufi, Emily Lerner, Peter E Fecci
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Within and beyond the tumor: Mechanisms of glioblastoma-induced immunosuppression.
Immunotherapies have thus far proved of limited efficacy against glioblastoma. Failures can be attributed to a host of immunosuppressive mechanisms that are either directly employed by the tumor or are instead a convenient feature of the intracranial environment. This review aims to categorize glioblastoma immune-evasive tendencies, provide an update on our understanding of etiologies, and describe newer approaches to improving therapeutic responses.
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