数字动物模型的伦理和法律考虑：开创性的减少和替代。

IF 14.9 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2025-09-10 DOI:10.1016/j.tibtech.2025.08.011

Federico Germani, Julian W März, Alessandro Luciani, Olivier Devuyst, Nikola Biller-Andorno

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引用次数: 0

摘要

数字动物模型的发展为推进生物医学研究中减少和替代的伦理原则提供了一条有希望的途径。本文讨论了建立在人工智能（AI）生成的模拟模式生物特征和行为的合成数据集上的模型的潜力，减少了研究中对活体动物的依赖。

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Ethical and legal considerations of digital animal models: pioneering reduction and replacement.

The development of digital animal models represents a promising avenue for advancing the ethical principles of reduction and replacement in biomedical research. This paper discusses the potential of models built upon artificial intelligence (AI)-generated synthetic datasets simulating the characteristics and behaviors of model organisms, reducing reliance on live animals in research.

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).