帕金森病和孤立性快速眼动睡眠行为障碍患者肠道微生物群的差异

IF 5 3区医学 Q2 NEUROSCIENCES

Journal of Parkinson's disease Pub Date : 2025-09-12 DOI:10.1177/1877718X251354931

Alba Troci, Julienne Haas, Anna Weiß, Sebastian Heinzel, Andre Franke, Daniela Berg, Corinna Bang, Eva Schaeffer

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引用次数: 0

摘要

先前的研究表明，帕金森病（PD）患者的微生物群与健康对照组（HC）存在差异。为了推断可能的因果关系，检查前驱期的变化是高度相关的。本研究对孤立性快速眼动睡眠行为障碍（iRBD, n = 32）患者粪便样本中的微生物组与临床PD （n = 23）和HC （n = 34）进行了研究，发现PD和iRBD患者的β -多样性与HC相比发生了显著变化（p = 0.025; p = 0.003）， iRBD和PD的促炎物种增加，PD的scfa生成细菌减少。

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Differences in intestinal microbiota in Parkinson's disease and isolated REM sleep behavior disorder.

Previous studies have shown differences in the microbiota of patients with Parkinson's disease (PD) compared to healthy controls (HC). To deduce a possible causality, it is highly relevant to examine changes in the prodromal phase. This study investigated the microbiome in stool samples of individuals with isolated REM sleep behavior disorder (iRBD, n = 32) compared to clinical PD (n = 23) and HC (n = 34) and showed significant changes of beta-diversity in PD and iRBD patients compared to HC (p = 0.025; p = 0.003), with an increase in proinflammatory species in iRBD and PD and decrease in SCFA-producing bacteria in PD.

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.