Junyi Zhang, Junxiao Shen, Zujie Chen, Luyuan Lu, Jianwei Wang
{"title":"1990-2021年全球女性主要泌尿系统疾病负担：2021年全球疾病负担研究的系统分析","authors":"Junyi Zhang, Junxiao Shen, Zujie Chen, Luyuan Lu, Jianwei Wang","doi":"10.2147/IJWH.S543955","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The global health burden faced by women remains underappreciated, particularly with regard to urologic diseases.</p><p><strong>Purpose: </strong>This study aims to assess the patterns and temporal trends of four major urinary conditions in women including urinary tract infections (UTIs), urolithiasis, kidney cancer, and bladder cancer from 1990 to 2021.</p><p><strong>Patients and methods: </strong>We obtained data from the Global Burden of Disease (GBD) Study 2021, which provides estimates of incidence and disability-adjusted life years (DALYs) for urologic diseases in women across 204 countries and territories from 1990 to 2021. To assess temporal trends, we calculated the estimated annual percentage change (EAPC) in age-standardized incidence rates (ASRs) by region. Age-specific patterns were further evaluated through stratified analyses of incidence and DALYs across the life course.</p><p><strong>Results: </strong>In 2021, the global incidence of urologic diseases in women continued to rise. Country- and region-specific analyses revealed diverse trends in incidence rates and DALYs. Analysis of the EAPC in 2021 showed a positive correlation between the age-standardized death rate (ASDR) of UTIs and the Human Development Index (HDI), whereas bladder cancer ASDR was negatively correlated with HDI. Risk factor analysis indicated that smoking and poor metabolic health exacerbate the burden of kidney and bladder cancers. Additionally, both DALYs and incidence rates varied markedly across age groups. While the age-standardized incidence rates (ASIR) and ASDR for urolithiasis remained relatively stable over time, UTIs, as well as kidney and bladder cancers showed a slight increase projected beyond 2032.</p><p><strong>Conclusion: </strong>The burden of four major urologic diseases in women constitutes a significant global public health challenge. The diverse disease patterns underscore the importance of developing tailored, country-specific prevention and healthcare strategies based on local risk factor profiles. Our findings offer critical evidence to guide targeted public health policies.</p>","PeriodicalId":14356,"journal":{"name":"International Journal of Women's Health","volume":"17 ","pages":"2869-2883"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417710/pdf/","citationCount":"0","resultStr":"{\"title\":\"Global Burden of Major Urologic Diseases in Women, 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021.\",\"authors\":\"Junyi Zhang, Junxiao Shen, Zujie Chen, Luyuan Lu, Jianwei Wang\",\"doi\":\"10.2147/IJWH.S543955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The global health burden faced by women remains underappreciated, particularly with regard to urologic diseases.</p><p><strong>Purpose: </strong>This study aims to assess the patterns and temporal trends of four major urinary conditions in women including urinary tract infections (UTIs), urolithiasis, kidney cancer, and bladder cancer from 1990 to 2021.</p><p><strong>Patients and methods: </strong>We obtained data from the Global Burden of Disease (GBD) Study 2021, which provides estimates of incidence and disability-adjusted life years (DALYs) for urologic diseases in women across 204 countries and territories from 1990 to 2021. To assess temporal trends, we calculated the estimated annual percentage change (EAPC) in age-standardized incidence rates (ASRs) by region. Age-specific patterns were further evaluated through stratified analyses of incidence and DALYs across the life course.</p><p><strong>Results: </strong>In 2021, the global incidence of urologic diseases in women continued to rise. Country- and region-specific analyses revealed diverse trends in incidence rates and DALYs. Analysis of the EAPC in 2021 showed a positive correlation between the age-standardized death rate (ASDR) of UTIs and the Human Development Index (HDI), whereas bladder cancer ASDR was negatively correlated with HDI. Risk factor analysis indicated that smoking and poor metabolic health exacerbate the burden of kidney and bladder cancers. Additionally, both DALYs and incidence rates varied markedly across age groups. While the age-standardized incidence rates (ASIR) and ASDR for urolithiasis remained relatively stable over time, UTIs, as well as kidney and bladder cancers showed a slight increase projected beyond 2032.</p><p><strong>Conclusion: </strong>The burden of four major urologic diseases in women constitutes a significant global public health challenge. The diverse disease patterns underscore the importance of developing tailored, country-specific prevention and healthcare strategies based on local risk factor profiles. 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Global Burden of Major Urologic Diseases in Women, 1990-2021: A Systematic Analysis for the Global Burden of Disease Study 2021.
Background: The global health burden faced by women remains underappreciated, particularly with regard to urologic diseases.
Purpose: This study aims to assess the patterns and temporal trends of four major urinary conditions in women including urinary tract infections (UTIs), urolithiasis, kidney cancer, and bladder cancer from 1990 to 2021.
Patients and methods: We obtained data from the Global Burden of Disease (GBD) Study 2021, which provides estimates of incidence and disability-adjusted life years (DALYs) for urologic diseases in women across 204 countries and territories from 1990 to 2021. To assess temporal trends, we calculated the estimated annual percentage change (EAPC) in age-standardized incidence rates (ASRs) by region. Age-specific patterns were further evaluated through stratified analyses of incidence and DALYs across the life course.
Results: In 2021, the global incidence of urologic diseases in women continued to rise. Country- and region-specific analyses revealed diverse trends in incidence rates and DALYs. Analysis of the EAPC in 2021 showed a positive correlation between the age-standardized death rate (ASDR) of UTIs and the Human Development Index (HDI), whereas bladder cancer ASDR was negatively correlated with HDI. Risk factor analysis indicated that smoking and poor metabolic health exacerbate the burden of kidney and bladder cancers. Additionally, both DALYs and incidence rates varied markedly across age groups. While the age-standardized incidence rates (ASIR) and ASDR for urolithiasis remained relatively stable over time, UTIs, as well as kidney and bladder cancers showed a slight increase projected beyond 2032.
Conclusion: The burden of four major urologic diseases in women constitutes a significant global public health challenge. The diverse disease patterns underscore the importance of developing tailored, country-specific prevention and healthcare strategies based on local risk factor profiles. Our findings offer critical evidence to guide targeted public health policies.
期刊介绍：
International Journal of Women''s Health is an international, peer-reviewed, open access, online journal. Publishing original research, reports, editorials, reviews and commentaries on all aspects of women''s healthcare including gynecology, obstetrics, and breast cancer. Subject areas include: Chronic conditions including cancers of various organs specific and not specific to women Migraine, headaches, arthritis, osteoporosis Endocrine and autoimmune syndromes - asthma, multiple sclerosis, lupus, diabetes Sexual and reproductive health including fertility patterns and emerging technologies to address infertility Infectious disease with chronic sequelae including HIV/AIDS, HPV, PID, and other STDs Psychological and psychosocial conditions - depression across the life span, substance abuse, domestic violence Health maintenance among aging females - factors affecting the quality of life including physical, social and mental issues Avenues for health promotion and disease prevention across the life span Male vs female incidence comparisons for conditions that affect both genders.
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