Muazzam Arif, Humaira Nadeem, Zaman Ashraf, Muhammad Tariq Khan, Tayyaba Anwar, Rizwan Hafeez
{"title":"新型噻唑烷-4-羧酸衍生物的合成及其对甲型流感的抑制作用。","authors":"Muazzam Arif, Humaira Nadeem, Zaman Ashraf, Muhammad Tariq Khan, Tayyaba Anwar, Rizwan Hafeez","doi":"10.1080/17568919.2025.2559575","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>This study explored the synthesis and evaluation of novel neuraminidase (NA) inhibitors, focusing on thiazolidine-4-carboxylic acid derivatives to combat influenza.</p><p><strong>Materials and methods: </strong>The synthesized compounds were evaluated for their NA inhibitory activity and assessed against Influenza A (H7N3) using hemagglutination inhibition (HAI) assays. Molecular docking studies were also conducted to support the experimental findings.</p><p><strong>Results: </strong>Compounds 4a, 4b, and 6a demonstrated potent NA inhibitory activity. While all compounds showed moderate HAI activity compared to Oseltamivir, 4a and 8a exhibited strong potency with low Mean MIC values against the H7N3 strain.</p><p><strong>Conclusions: </strong>These findings suggest that the thiazolidine derivatives hold potential as novel inhibitory agents against influenza. Future research will focus on assessing their toxicity and safety profiles, paving the way for the development of effective and safer NA inhibitors.</p>","PeriodicalId":12475,"journal":{"name":"Future medicinal chemistry","volume":" ","pages":"2379-2389"},"PeriodicalIF":3.4000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490399/pdf/","citationCount":"0","resultStr":"{\"title\":\"Novel thiazolidine-4-carboxylic acid derivatives: synthesis and inhibitory effects against influenza A.\",\"authors\":\"Muazzam Arif, Humaira Nadeem, Zaman Ashraf, Muhammad Tariq Khan, Tayyaba Anwar, Rizwan Hafeez\",\"doi\":\"10.1080/17568919.2025.2559575\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>This study explored the synthesis and evaluation of novel neuraminidase (NA) inhibitors, focusing on thiazolidine-4-carboxylic acid derivatives to combat influenza.</p><p><strong>Materials and methods: </strong>The synthesized compounds were evaluated for their NA inhibitory activity and assessed against Influenza A (H7N3) using hemagglutination inhibition (HAI) assays. Molecular docking studies were also conducted to support the experimental findings.</p><p><strong>Results: </strong>Compounds 4a, 4b, and 6a demonstrated potent NA inhibitory activity. While all compounds showed moderate HAI activity compared to Oseltamivir, 4a and 8a exhibited strong potency with low Mean MIC values against the H7N3 strain.</p><p><strong>Conclusions: </strong>These findings suggest that the thiazolidine derivatives hold potential as novel inhibitory agents against influenza. Future research will focus on assessing their toxicity and safety profiles, paving the way for the development of effective and safer NA inhibitors.</p>\",\"PeriodicalId\":12475,\"journal\":{\"name\":\"Future medicinal chemistry\",\"volume\":\" \",\"pages\":\"2379-2389\"},\"PeriodicalIF\":3.4000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12490399/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Future medicinal chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/17568919.2025.2559575\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/9/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Future medicinal chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/17568919.2025.2559575","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Novel thiazolidine-4-carboxylic acid derivatives: synthesis and inhibitory effects against influenza A.
Aims: This study explored the synthesis and evaluation of novel neuraminidase (NA) inhibitors, focusing on thiazolidine-4-carboxylic acid derivatives to combat influenza.
Materials and methods: The synthesized compounds were evaluated for their NA inhibitory activity and assessed against Influenza A (H7N3) using hemagglutination inhibition (HAI) assays. Molecular docking studies were also conducted to support the experimental findings.
Results: Compounds 4a, 4b, and 6a demonstrated potent NA inhibitory activity. While all compounds showed moderate HAI activity compared to Oseltamivir, 4a and 8a exhibited strong potency with low Mean MIC values against the H7N3 strain.
Conclusions: These findings suggest that the thiazolidine derivatives hold potential as novel inhibitory agents against influenza. Future research will focus on assessing their toxicity and safety profiles, paving the way for the development of effective and safer NA inhibitors.
期刊介绍：
Future Medicinal Chemistry offers a forum for the rapid publication of original research and critical reviews of the latest milestones in the field. Strong emphasis is placed on ensuring that the journal stimulates awareness of issues that are anticipated to play an increasingly central role in influencing the future direction of pharmaceutical chemistry. Where relevant, contributions are also actively encouraged on areas as diverse as biotechnology, enzymology, green chemistry, genomics, immunology, materials science, neglected diseases and orphan drugs, pharmacogenomics, proteomics and toxicology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
