Ming Zhao, Jiayue Zhang, Qianqian Yang, Lei Chen, Hongjian Shen, Yingyan Pu, Wei Wei, Yi Han, Ping Zhang
{"title":"MATK在慢性低灌注伴白质高信号患者中的表达及相关性研究。","authors":"Ming Zhao, Jiayue Zhang, Qianqian Yang, Lei Chen, Hongjian Shen, Yingyan Pu, Wei Wei, Yi Han, Ping Zhang","doi":"10.3389/fnagi.2025.1570482","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI). Patients with CCH frequently exhibit white matter hyperintensities (WMH) on MRI. This study investigated the expression and clinical relevance of megakaryocyte-associated tyrosine kinase (MATK) in CCH patients with WMH.</p><p><strong>Methods: </strong>We recruited 42 anterior circulation stenosis patients with CCH and WMH (CCH-WMH group) and 45 age-matched healthy controls. MATK mRNA expression in peripheral blood mononuclear cells (PBMCs) was quantified using qPCR. WMH severity was graded using the Fazekas scale. Correlations between MATK expression and imaging/clinical parameters were analyzed using Pearson's correlation and logistic regression. Diagnostic performance was assessed via ROC analysis.</p><p><strong>Results: </strong>Megakaryocyte-associated tyrosine kinase expression was significantly downregulated in the CCH-WMH group versus controls (1.20 ± 0.99 vs. 1.84 ± 0.87; <i>P</i> < 0.01). MATK levels showed a strong negative correlation with Fazekas scores (R<sup>2</sup> = 0.3405, <i>P</i> < 0.001). Multivariate regression identified MATK as independently associated with WMH (aOR = 0.492; 95% CI: 0.262-0.923; <i>P</i> = 0.027). ROC analysis demonstrated moderate diagnostic accuracy for WMH (AUC = 0.743; 95% CI: 0.637-0.849).</p><p><strong>Conclusion: </strong>Reduced peripheral MATK expression correlates with WMH severity in CCH patients and may serve as a potential diagnostic biomarker.</p>","PeriodicalId":12450,"journal":{"name":"Frontiers in Aging Neuroscience","volume":"17 ","pages":"1570482"},"PeriodicalIF":4.5000,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417534/pdf/","citationCount":"0","resultStr":"{\"title\":\"The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity.\",\"authors\":\"Ming Zhao, Jiayue Zhang, Qianqian Yang, Lei Chen, Hongjian Shen, Yingyan Pu, Wei Wei, Yi Han, Ping Zhang\",\"doi\":\"10.3389/fnagi.2025.1570482\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI). Patients with CCH frequently exhibit white matter hyperintensities (WMH) on MRI. This study investigated the expression and clinical relevance of megakaryocyte-associated tyrosine kinase (MATK) in CCH patients with WMH.</p><p><strong>Methods: </strong>We recruited 42 anterior circulation stenosis patients with CCH and WMH (CCH-WMH group) and 45 age-matched healthy controls. MATK mRNA expression in peripheral blood mononuclear cells (PBMCs) was quantified using qPCR. WMH severity was graded using the Fazekas scale. Correlations between MATK expression and imaging/clinical parameters were analyzed using Pearson's correlation and logistic regression. Diagnostic performance was assessed via ROC analysis.</p><p><strong>Results: </strong>Megakaryocyte-associated tyrosine kinase expression was significantly downregulated in the CCH-WMH group versus controls (1.20 ± 0.99 vs. 1.84 ± 0.87; <i>P</i> < 0.01). MATK levels showed a strong negative correlation with Fazekas scores (R<sup>2</sup> = 0.3405, <i>P</i> < 0.001). Multivariate regression identified MATK as independently associated with WMH (aOR = 0.492; 95% CI: 0.262-0.923; <i>P</i> = 0.027). ROC analysis demonstrated moderate diagnostic accuracy for WMH (AUC = 0.743; 95% CI: 0.637-0.849).</p><p><strong>Conclusion: </strong>Reduced peripheral MATK expression correlates with WMH severity in CCH patients and may serve as a potential diagnostic biomarker.</p>\",\"PeriodicalId\":12450,\"journal\":{\"name\":\"Frontiers in Aging Neuroscience\",\"volume\":\"17 \",\"pages\":\"1570482\"},\"PeriodicalIF\":4.5000,\"publicationDate\":\"2025-08-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417534/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Aging Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3389/fnagi.2025.1570482\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Aging Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3389/fnagi.2025.1570482","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity.
Background: Chronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI). Patients with CCH frequently exhibit white matter hyperintensities (WMH) on MRI. This study investigated the expression and clinical relevance of megakaryocyte-associated tyrosine kinase (MATK) in CCH patients with WMH.
Methods: We recruited 42 anterior circulation stenosis patients with CCH and WMH (CCH-WMH group) and 45 age-matched healthy controls. MATK mRNA expression in peripheral blood mononuclear cells (PBMCs) was quantified using qPCR. WMH severity was graded using the Fazekas scale. Correlations between MATK expression and imaging/clinical parameters were analyzed using Pearson's correlation and logistic regression. Diagnostic performance was assessed via ROC analysis.
Results: Megakaryocyte-associated tyrosine kinase expression was significantly downregulated in the CCH-WMH group versus controls (1.20 ± 0.99 vs. 1.84 ± 0.87; P < 0.01). MATK levels showed a strong negative correlation with Fazekas scores (R2 = 0.3405, P < 0.001). Multivariate regression identified MATK as independently associated with WMH (aOR = 0.492; 95% CI: 0.262-0.923; P = 0.027). ROC analysis demonstrated moderate diagnostic accuracy for WMH (AUC = 0.743; 95% CI: 0.637-0.849).
Conclusion: Reduced peripheral MATK expression correlates with WMH severity in CCH patients and may serve as a potential diagnostic biomarker.
期刊介绍：
Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.
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